Characterization of Hemostatic Disordres in Septic Shock: Searching for Biological Markers

Characterization of Hemostatic Disordres in Septic Shock: Searching for Biological Markers

Sepsis induces hemostatic disorders due to the exessive or inappropriate activation of inflammation, which could lead either to hypercoagulability or hypocoagulability. It is currently not possible to determine the hemostatic status of a given patient. This instability of hemostatic system is not revealed by classical tests. Thus, a better characterization of hemostatic status could certainly improve patient care. This study aims at characterizing disorders of coagulation and fibrinolysis using "global" tests such as thrombin generation test or coagulolytic test. Furthermore, the association with biological markers of interest (such as microparticles, neutrophil elastase or histones) will be evaluated.

Eligibility criteria for patients with septic schock

Inclusion Criteria:

• septic shock (Dellinger, 2013)
• age >18y
• hospitalized patients
• signature of an informed consent (emergency consent)
• affiliation to a social security regimen

Exclusion Criteria:

• pregnancy or breast-feeding women
• moribund patient
• oral anticoagulant therapy
• thrombophilia
• Minor patients
• Patients under tutelage

Eligibility criteria from subject without septic shock Subject blood samples without septic shock are collected from a historical healthy volunteers cohort.