Comparison of Intra-operative Radiotherapy With Post-operative Radiotherapy for Women With Ductal Carcinoma in Situ

Comparison of the Efficacy of Intra-operative Radiation Therapy After Conserving Surgery With Post-operative Whole Breast Radiotherapy for Women With Ductal Carcinoma in Situ

Radiation therapy uses high-energy x-rays to damage tumor cells. Giving radiation during surgery followed by external-beam radiation to the entire breast may kill more tumor cells.The clinical trial is conducting to compare the effectiveness of radiation therapy during surgery and whole-breast radiation therapy in treating women who have undergone breast-conversing surgery for Intermediate or high grade ductal carcinoma in situ breast cancer.

Inclusion Criteria:

• Tumor diameter < 5 cm
• Intermediate or high grade ductal carcinoma in situ
• Informed consent

Exclusion Criteria:

• No informed consent
• Tumor size > 3,5 cm
• Low grade ductal carcinoma in situ
• Invasive carcinoma
• No indication for a boost