Cardiovascular, Renal and Metabolic Profile in Patients With Acute Myocardial Infarction (REN-ACS)

Cardiovascular, Renal and Metabolic Profile in Patients With Acute Myocardial Infarction (AMI) Included in the Romanian National Programme of Primary Percutaneous Revascularisation - a Single Center Observational Study

Aims

• assessment of renal artery stenosis incidence in consecutive AMI patients included in the Romanian National Programme of Primary Percutaneous Revascularisation;
• generating a cardio-renal-metabolic profile in patients with renal atherosclerotic disease;
• creating a local registry (based on European CARDS percutaneous interventional registries) which also includes renal, metabolic and vascular data;
• reporting long-term follow-up data on major cardiac adverse events (MACE) in the study group.

Gathered data:

• descriptive general demographic data;
• previous pathologies (ischemic heart disease, peripheral arterial disease, stroke, heart failure, previous percutaneous coronary interventions, coronary artery bypass grafting - CABG, known renal disease), cardiovascular risk factors (age, weight, height, abdominal perimeter, body mass index, smoking, sedentariness, diabetes, hypertension, dyslipidaemia);
• routine biological data and specific non-genetic biomarkers;
• information regarding primary PCI (less than 12 hours of ischemic symptoms): coronarographic details, type of used stent, periprocedural specific complications, final TIMI - thrombolysis in myocardial infarction - flow);
• echocardiography at admission (LVEF);
• metabolic data (obtained from body composition monitoring) - body water, body fat tissue;
• renal arteries angiographic details (two independent operators evaluate stenosis based on a predefined scale);
• renal dimensions;
• measurement of arterial stiffness through Sphigmocore pulsed-wave-velocity (24 hrs post-procedural, 2 velocities: carotid - femoral and carotid - radial);
• heart rate variability;
• in-hospital and one month follow-up MACE;

Inclusion Criteria:

• adults with AMI (<12h) diagnostic confirmed;
• included in the Romanian National Programme of Primary Percutaneous Revascularisation (for who the Guidelines recommend primary PCI);

Exclusion Criteria:

• none