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This study evaluates the difference in pregnancy rate transferring a healthy blastocyst in natural or artificial cycle.
The aim of the study was to verify the implantation capacity and ongoing pregnancy rate of vitrified warmed euploid blastocyst in natural cycle versus endometrial artificial cycle with gonadotropin-releasing hormone (GnRH-agonist) pituitary suppression.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| natural cycle | Other | Ultrasound controls and endocrine blood test to asses the day of ovulation for embryo transfer |
|
| hormonal cycle | Active Comparator | Ultrasound controls and endocrine blood test to asses the endometrium thickness for embryo transfer |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| embryo transfer | Other | healthy blastocyst transfer in natural and hormonal cycle |
|
| Measure | Description | Time Frame |
|---|---|---|
| clinical pregnancy rate confirmed by ultrasound evidence of fetal heart activity | 12 weeks after embryo transfer |
| Measure | Description | Time Frame |
|---|---|---|
| live-birth rate confirmed by the number of born | term pregnancy delivery | |
| cost-benefit of two endometrial preparation protocol | Assessment of drug cost and the count of clinical visit, laboratory dosages and venous sampling |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| ERmanno Greco, MD | European Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| European Hospital | Rome | RM | 00149 | Italy | ||
| European Hospital |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27221477 | Derived | Greco E, Litwicka K, Arrivi C, Varricchio MT, Caragia A, Greco A, Minasi MG, Fiorentino F. The endometrial preparation for frozen-thawed euploid blastocyst transfer: a prospective randomized trial comparing clinical results from natural modified cycle and exogenous hormone stimulation with GnRH agonist. J Assist Reprod Genet. 2016 Jul;33(7):873-84. doi: 10.1007/s10815-016-0736-y. Epub 2016 May 24. |
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| ID | Term |
|---|---|
| D007246 | Infertility |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
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| ID | Term |
|---|---|
| D004624 | Embryo Transfer |
| ID | Term |
|---|---|
| D027724 | Reproductive Techniques, Assisted |
| D012099 | Reproductive Techniques |
| D013812 | Therapeutics |
| D008919 | Investigative Techniques |
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| 30 weeks beginning from day 21 of the previous cycle day up to the pregnancy test |
| The number of patients with the anxiety and depression increase | the psychological questionnaire (HADS) administered on four time point | Six weeks beginning on the day of treatment start, on the day of progesterone administration, on the day of blastocyst transfer and the pregnancy test |
| Rome |
| Roma |
| 00149 |
| Italy |