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Recent sutdies indicate that the existence of corpus lutein in the ovary is a key point to prevent preeclampsia, and patients undergoing FET with hormone replaced cycle have no corpus lutein and the absence of corpus lutein significantly increases the risk of preeclampsia in these patients. We aim to conduct a single center randomized trial study to compare the preeclampsia rate between the natural cycle and the hormone replaced cycle in patients undergoing FET.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| natural cycle for endometrium preparation | Other | patients will have ovulation before embryo transfer |
|
| hormone replaced cycle for endometrium preparation | Experimental | patients will do not have ovulation before embryo transfer |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| natural cycle for endometrium preparation | Other | patients will not use oral contraceptive drugs |
|
| Measure | Description | Time Frame |
|---|---|---|
| live birth rate | A delivery is considered successful live birth | delivery |
| Measure | Description | Time Frame |
|---|---|---|
| pre-eclampsia | Preeclampsia is defined using the current American College of Obstetricians and Gynecologists definitions (Gynecologists; and Pregnancy 2013) | From gestational week 20 to delivery |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Dan Zhang, M.D. Ph.D. | Contact | 86-0571-87061501-1008 | zhangdan@zju.edu.cn | |
| Kai-Lun Hu, M.D. | Contact | 86-010-15901575271 | hukailun@bjmu.edu.cn |
| Name | Affiliation | Role |
|---|---|---|
| Dan Zhang, M.D. Ph.D. | Women's Hospital School Of Medicine Zhejiang University | Principal Investigator |
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| ID | Term |
|---|---|
| D011225 | Pre-Eclampsia |
| ID | Term |
|---|---|
| D046110 | Hypertension, Pregnancy-Induced |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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| hormone replaced cycle for endometrium preparation | Other | patients will receive oral contraceptive drugs for menstruation before embryo transfer |
|
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