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There are no solid treatment guidelines for idiopathic intractable epilepsy in children. The investigators propose that vitamin C being an antioxidant will improve seizure frequency and EEG in children with idiopathic intractable epilepsy.
Is vitamin C; being an antioxidant based on the hypothesis of oxidative stress as a provocation factor for idiopathic epilepsy low in those with idiopathic epilepsy, and is it lower in those with refractory than those with newly diagnosed? Will vitamin C supplementation for 1 month be efficient to raise the vitamin C level and will it improve seizures and EEG findings in those with idiopathic epilepsy?
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Vitamin C supplemented | Experimental | patients with refractory idiopathic epilepsy will receive vitamin C supplement according to age for 1 month |
|
| None supplemented | No Intervention | followed up for 1 month |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Vitamin C | Dietary Supplement | those who are 2-3 years will receive 400 mg/day, 4-8 years will receive 500 mg/day, those who are 9-13 years will receive 1000 mg/day, and from 14-16 years will receive 1500 mg/day |
| Measure | Description | Time Frame |
|---|---|---|
| Seizure severity and frequency, EEG findings | Seizure severity based on the Chalfont seizre severity scale and daily seizure frequency will be measured before and 30 days after vitamin C supplementation in children with intractable idiopathic epilepsy | up to 30 days |
| Measure | Description | Time Frame |
|---|---|---|
| vitamin C level in children with epilepsy | children with epilepsy will be recruited over a period of 6 months and we will measure vitamin C level in their blood | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Iman A Elagouza, A Professor | Faculty of Medicine, Ain Shams University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shaymaa Maher Deifalla | Cairo | Nasr City | Egypt |
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| ID | Term |
|---|---|
| D001205 | Ascorbic Acid |
| ID | Term |
|---|---|
| D013400 | Sugar Acids |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
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| D006880 |
| Hydroxy Acids |
| D002241 | Carbohydrates |