Diagnosis of Central Adrenal Insufficiency in Patients With Prader-Willi Syndrome

Diagnosis of Central Adrenal Insufficiency in Patients With Prader-Willi Syndrome

The purpose of this study is to determine presence of central adrenal insufficiency in children with Prader Willi Syndrome using low dose (1 mcg) ACTH stimulation test compared to results of overnight metyrapone test.

Inclusion Criteria:

• Individuals with Prader Willi Syndrome ages 2 years and older

Exclusion Criteria:

• Individuals who are ill at the time of study
• Individuals who are pregnant at the time of study
• Individuals who it is deemed unsafe to stop taking medications known to affect the results of they study (hydrocortisone, phenytoin, estrogen, acetaminophen, oral anti-diabetic agents).