Cortisol Activity in Patients With Prader-Willi Syndrome and Healthy Controls

11 Beta Hydroxysteroid Dehydrogenase 1 (11-beta HSD 1) Activity in Patients With Prader-Willi Syndrome and in Healthy Controls

The purpose of the study is to find out if people with Prader-Willi syndrome have a difference in the protein which changes inactive cortisone to the active stress hormone cortisol.

Inclusion Criteria:

• Prader-Willi syndrome confirmed by molecular testing, ages 6 months to adult
• Controls: Age-matched, sex-matched, developmentally normal, BMI-controlled healthy or obese subjects

Exclusion Criteria:

• PWS subjects without molecular confirmation of the diagnosis
• Subjects receiving glucocorticoid treatment within 3 months of evaluation
• Subjects receiving growth hormone within one year prior to analysis