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The aim of this study is determining the affects of serum vitamin D levels to implantation and clinical pregnancy rates in women undergoing elective vitrified/thawed embryo transfer. Two groups will be identified according to the serum vitamin D levels on eFET transfer day and later on implantation, clinical pregnancy and ongoing pregnancy rates will be compared between those groups
In the last decade there have been growing evidence about Vitamin D receptors and their role in female genital tract. But these studies are yet not well designed and the results should be interpreted cautiously. Although some of these studies advocating the Vitamin D deficiency as an negative circumstance on pregnancy rates some of the others don't agree. According to contradictory results understanding the actual role of those receptors needs more observation.
Latest retrospective analyse postulated that, vitamin D deficiency in fresh single embryo transfer cycles may reduce pregnancy rates mediated by endometrium or ovarian reserve and stimulation characteristics.
For this reason the investigators aimed to explore the effect of serum Vitamin D levels on pregnancy rates in infertile population undergoing frozen embryo transfer.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| vitamin D deficient patients | Serum 25- (hydroxide) OH Vitamin D levels <20ng/L undergoing Frozen embryo transfer (Vitamin D levels are measured on the day of embryo transfer) |
| |
| vitamin D sufficient patients | Serum 25- (hydroxide) OH Vitamin D levels >20ng/L undergoing Frozen embryo transfer (Vitamin D levels are measured on the day of embryo transfer) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| frozen embryo transfer | Procedure | comparison of groups according to their serum vitamin D levels on frozen embryo transfer day |
|
| Measure | Description | Time Frame |
|---|---|---|
| clinical pregnancy rate | The presence of intrauterine gestational sac at 7 weeks of gestation | 4 weeks after embryo transfer |
| Measure | Description | Time Frame |
|---|---|---|
| implantation rates | number of gestational sacs per transferred embryo. | 3 weeks after embryo transfer |
| ongoing pregnancy rates | Pregnancy that had completed ≥20 weeks of gestation |
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Inclusion Criteria:
Exclusion Criteria:
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Infertile women undergoing a frozen ET with 1 Day 5 (blastocyst stage) embryo
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| cem celik | Contact | +905324205365 | cemcel@yahoo.com | |
| kubra n boynukalin | Contact | +905336412040 | kboynukalin@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| mustafa bahceci | bahceci Fulya IVF center | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Bahceci Fulya IVF Center | Recruiting | Istanbul | Fulya | 34800 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22914766 | Background | Rudick B, Ingles S, Chung K, Stanczyk F, Paulson R, Bendikson K. Characterizing the influence of vitamin D levels on IVF outcomes. Hum Reprod. 2012 Nov;27(11):3321-7. doi: 10.1093/humrep/des280. Epub 2012 Aug 21. |
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| 18 weeks after embryo transfer |