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Objective: To examine the effect of vitamin D supplements on the pregnancy and clinical pregnancy rate in embryo transfer cycles.
Design: Experimental study with a pre- and post-test. Setting: In Vitro Fertilization Center Patients: Its sample consisted of 118 women, 58 in the experimental group and 60 in the control group.
Intervention(s): At the beginning of the infertility treatment, the experimental group took vitamin D supplements, and the control group did not. Vitamin D supplementation for infertile women includes regulation of a diet rich in vitamin D, educational and motivational interviews about insolation, and taking vitamin D orally.
Main Outcome Measure(s): 25(OH)D and beta HCG levels
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Experimental | Experimental |
| |
| Control | No Intervention |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| DEVIT-3 | Drug | The physicians gave the women in the experimental group vitamin D oral drops in an ampoule of 300,000 IU and a vial of 50,000 IU to take during the IVF treatment. Written and verbal information about how to take vitamin D was provided to the participants by the nurses. The women took 300,000 IU vitamin D orally for the first week. In the second week of the treatment, 50,000 IU vitamin D (15 drops/day) was used as maintenance dose until the pregnancy test day. |
| Measure | Description | Time Frame |
|---|---|---|
| Blood Vitamin D level | The vitamin D blood test was measured by the level of 25(OH)D. | The 25 (OH)D levels of the experimental group women were tested on the second or third day of their menstrual cycle. (Pretest) |
| Blood Vitamin D level | The vitamin D blood test was measured by the level of 25(OH)D. | The 25 (OH)D levels of the women were tested on the two weeks after embryo transfer. (Posttest) |
| Measure | Description | Time Frame |
|---|---|---|
| Biochemical pregnancy | The pregnancy test was measured level of HCG in the blood. | HCG levels of the women were evaluated on the two weeks after embryo transfer (Post test) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Gamze Teskereci | Akdeniz University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Murat Özekinci | Antalya | Turkey (Türkiye) |
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| ID | Term |
|---|---|
| D007246 | Infertility |
| D007247 | Infertility, Female |
| D014808 | Vitamin D Deficiency |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
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|
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D001361 | Avitaminosis |
| D003677 | Deficiency Diseases |
| D044342 | Malnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |