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The investigators conducted a pilot study to compare the effect of Positive End Expiratory Pressure(PEEP) setting guide by lung electrical impedance tomography(EIT) and ARDS-net PEEP-FiO2 table on survival in subjects with mild/severe Acute Respiratory Distress Syndrome(ARDS).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| EIT group | Experimental | the Individualized PEEP titration by EIT was administered to the patients in the EIT group. |
|
| control group | No Intervention | If patients are assigned to the control group, the Individualized PEEP Setting was by PEEP-FiO2 table based on ARDS-net protocol. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| the EIT guide the individualized PEEP Setting | Other | the EIT guide the individualized PEEP Setting in the EIT group |
|
| Measure | Description | Time Frame |
|---|---|---|
| survival | Non-survive and survive | 28-day |
| Arterial oxygenation | PaO2(mmHg) measured by blood gas analysis | 72h |
| Measure | Description | Time Frame |
|---|---|---|
| length of ICU stay and mechanical ventilated day | Days of ICU stay and received mechanical ventilation(day) | 28days |
| pneumothorax requiring chest tube during first 7 days; barotrauma during first 7 days; |
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Inclusion:
Exclusion:
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| Name | Affiliation | Role |
|---|---|---|
| Yun Long, MD | Department of Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, | Beijing | Beijing Municipality | 100730 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34193224 | Derived | He H, Chi Y, Yang Y, Yuan S, Long Y, Zhao P, Frerichs I, Fu F, Moller K, Zhao Z. Early individualized positive end-expiratory pressure guided by electrical impedance tomography in acute respiratory distress syndrome: a randomized controlled clinical trial. Crit Care. 2021 Jun 30;25(1):230. doi: 10.1186/s13054-021-03645-y. |
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new-onset of pneumothorax and barotrauma
| 7days |