Predictive Factors and Subthalamic Stimulation in Parkinson's Disease

Predictive Factors for Therapeutic Response of Subthalamic Stimulation on Quality of Live in Parkinson's Disease

This study identify preoperative predictors of response to subthalamic stimulation at 1 year, 3 years and 5 years in terms of quality of life, from a broad prospective multicenter study French with standardized collection of clinical data , imaging and genetic .

The investigators want to identify factors that predict the improvement of quality of life for one year corresponding to a decrease of PDQ39 score of at least 20 %. They believe that improvement would be less likely to become zero to 3 or 5 years and question the indication of the subthalamic stimulation (risks and costs). This is part of a process of "personalization" of the therapeutic care that is of any interest to the subthalamic stimulation. It is a therapeutic option that could be dangerous if patient selection is not optimal , and expensive, if the benefit is not large enough to reduce the number of medications and hospitalizations medium term . In addition, it will quantify the improvement of quality of life in the longer term and harmonize national assessments .

Inclusion Criteria:

• Patients receiving a pre- therapeutic assessment and therapeutic monitoring for one year , 3 years and 5 years as part of the regular monitoring of the subthalamic stimulation
• Bilateral STN stimulation considered
• Patient able to provide their free and informed consent
• Patient with insurance coverage

Exclusion Criteria:

• Atypical Parkinson's disease do not meet the criteria of stuff .
• MP under 5 years
• Severe cognitive impairment or dementia ( Score Moca <24 and DSM-IV criteria)
• Parkinson's Psychosis
• Reply to L- dopa <30 %
• Against indication for surgery
• Severe brain atrophy or abnormal MRI
• The presence of another very serious condition terminal life- short-term prognosis ( malignancy ) is an indication against .