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| ID | Type | Description | Link |
|---|---|---|---|
| 5F32AT007800-03 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Center for Complementary and Integrative Health (NCCIH) | NIH |
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New advances in medical imaging have allowed for the measurement of brain activity related to chronic pain. In addition to the brain, the investigators aim to use functional magnetic resonance imaging to investigate pain processing in the brainstem and spinal cord in healthy subjects and chronic neck pain patients. The information gained from this study will increase the investigators understanding of how chronic pain is encoded in the nervous system and assist in developing more effective treatment strategies.
The experimental design is an observational (non-interventional) cross-sectional clinical study. The principal goal of the proposed research is to utilize functional magnetic resonance imaging to further investigate and characterize pain-related neural activity at the level of the brain, brainstem, and spinal cord in healthy subjects and chronic neck pain patients. Healthy subjects and chronic neck pain patients will be recruited and participate in a single session of data collection. For both the healthy and chronic neck pain groups, painful thermal stimuli will be applied over the skin of the upper extremity while whole brain, brainstem, and cervical spinal cord functional images are acquired (on separate scans). For the chronic neck pain group, additional scans (brain, brainstem, and cervical spinal cord) will be acquired while the subjects rate their spontaneous chronic neck pain.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy subjects | Functional magnetic resonance imaging of healthy subjects |
| |
| Chronic neck pain patients | Functional magnetic resonance imaging of chronic neck pain patients |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Functional Magnetic Resonance Imaging | Other | Functional magnetic resonance imaging will be performed to measure brain, brainstem, and spinal cord activity. |
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| Measure | Description | Time Frame |
|---|---|---|
| Functional magnetic resonance imaging | Use functional magnetic resonance imaging to characterize brain, brainstem, and spinal cord pain processing in healthy subjects (thermal pain) and chronic neck pain patients (thermal pain and spontaneous clinical pain). | 1.5-2.25 hours |
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Healthy subjects must meet all of the following inclusion criteria to participate in this study:
Chronic neck pain patients must meet all of the following inclusion criteria to participate in this study:
Participants meeting any of the following exclusion criteria at baseline will be excluded from study participation:
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Healthy subjects and chronic neck pain patients recruited from the community
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| Name | Affiliation | Role |
|---|---|---|
| Todd Parrish, PhD | Northwestern University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Center for Translational Imaging, Northwestern University | Chicago | Illinois | 60611 | United States |
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| ID | Term |
|---|---|
| D019547 | Neck Pain |
| D059350 | Chronic Pain |
| ID | Term |
|---|---|
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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