Percentage of participants with carbon monoxide (CO)-verified self-report of continuous abstinence from smoking

Percentage of participants with carbon monoxide (CO)-verified self-report of continuous abstinence from smoking

Percentage of participants with carbon monoxide (CO)-verified self-report of continuous abstinence from smoking

Percentage of participants with carbon monoxide (CO)-verified self-report of continuous abstinence from smoking

Participants were asked if during the last 24 hours they experienced the desire/urge to smoke on a 5-grade categorical scale of 0 - 4 (where 0=not at all and 4=extremely so).

Participants were asked if during the last 24 hours they experienced the desire/urge to smoke on a 5-grade categorical scale of 0 - 4 (where 0=not at all and 4=extremely so).

Participants were asked if during the last 24 hours they experienced the desire/urge to smoke on a 5-grade categorical scale of 0 - 4 (where 0=not at all and 4=extremely so).

Participants were asked if during the last 24 hours they experienced the desire/urge to smoke on a 5-grade categorical scale of 0 - 4 (where 0=not at all and 4=extremely so).

Participants were asked if during the last 24 hours they experienced irritability/frustration/anger on a 5-grade categorical scale of 0 - 4 (where 0=not at all and 4=extremely so).

Participants were asked if during the last 24 hours they experienced irritability/frustration/anger on a 5-grade categorical scale of 0 - 4 (where 0=not at all and 4=extremely so).

Participants were asked if during the last 24 hours they experienced irritability/frustration/anger on a 5-grade categorical scale of 0 - 4 (where 0=not at all and 4=extremely so).

Participants were asked if during the last 24 hours they experienced irritability/frustration/anger on a 5-grade categorical scale of 0 - 4 (where 0=not at all and 4=extremely so).

Participants were asked if during the last 24 hours they experienced restlessness on a 5-grade categorical scale of 0 - 4 (where 0=not at all and 4=extremely so).

Participants were asked if during the last 24 hours they experienced restlessness on a 5-grade categorical scale of 0 - 4 (where 0=not at all and 4=extremely so).

Participants were asked if during the last 24 hours they experienced restlessness on a 5-grade categorical scale of 0 - 4 (where 0=not at all and 4=extremely so).

Participants were asked if during the last 24 hours they experienced restlessness on a 5-grade categorical scale of 0 - 4 (where 0=not at all and 4=extremely so).

Participants were asked if during the last 24 hours they experienced difficulty concentrating on a 5-grade categorical scale of 0 - 4 (where 0=not at all and 4=extremely so).

Participants were asked if during the last 24 hours they experienced difficulty concentrating on a 5-grade categorical scale of 0 - 4 (where 0=not at all and 4=extremely so).

Participants were asked if during the last 24 hours they experienced difficulty concentrating on a 5-grade categorical scale of 0 - 4 (where 0=not at all and 4=extremely so).

Participants were asked if during the last 24 hours they experienced difficulty concentrating on a 5-grade categorical scale of 0 - 4 (where 0=not at all and 4=extremely so).

Participants were asked if during the last 24 hours they experienced anxiety on a 5-grade categorical scale of 0 - 4 (where 0=not at all and 4=extremely so).

Participants were asked if during the last 24 hours they experienced anxiety on a 5-grade categorical scale of 0 - 4 (where 0=not at all and 4=extremely so).

Participants were asked if during the last 24 hours they experienced anxiety on a 5-grade categorical scale of 0 - 4 (where 0=not at all and 4=extremely so).

Participants were asked if during the last 24 hours they experienced anxiety on a 5-grade categorical scale of 0 - 4 (where 0=not at all and 4=extremely so).

Participants were asked if during the last 24 hours they experienced dysphoric or depressed mood on a 5-grade categorical scale of 0 - 4 (where 0=not at all and 4=extremely so).

Participants were asked if during the last 24 hours they experienced dysphoric or depressed mood on a 5-grade categorical scale of 0 - 4 (where 0=not at all and 4=extremely so).

Participants were asked if during the last 24 hours they experienced dysphoric or depressed mood on a 5-grade categorical scale of 0 - 4 (where 0=not at all and 4=extremely so).

Participants were asked if during the last 24 hours they experienced dysphoric or depressed mood on a 5-grade categorical scale of 0 - 4 (where 0=not at all and 4=extremely so).

Participants were asked if during the last 24 hours they experienced insomnia on a 5-grade categorical scale of 0 - 4 (where 0=not at all and 4=extremely so).

Participants were asked if during the last 24 hours they experienced insomnia on a 5-grade categorical scale of 0 - 4 (where 0=not at all and 4=extremely so).

Participants were asked if during the last 24 hours they experienced insomnia on a 5-grade categorical scale of 0 - 4 (where 0=not at all and 4=extremely so).

Participants were asked if during the last 24 hours they experienced insomnia on a 5-grade categorical scale of 0 - 4 (where 0=not at all and 4=extremely so).

Participants were asked if during the last 24 hours they experienced increased appetite on a 5-grade categorical scale of 0 - 4 (where 0=not at all and 4=extremely so).

Participants were asked if during the last 24 hours they experienced increased appetite on a 5-grade categorical scale of 0 - 4 (where 0=not at all and 4=extremely so).

Participants were asked if during the last 24 hours they experienced increased appetite on a 5-grade categorical scale of 0 - 4 (where 0=not at all and 4=extremely so).

Participants were asked if during the last 24 hours they experienced increased appetite on a 5-grade categorical scale of 0 - 4 (where 0=not at all and 4=extremely so).

Participants were asked if during the last 24 hours they experienced each of 7 withdrawal symptoms on a 5-grade categorical scale of 0 - 4 (where 0=not at all and 4=extremely so). The aggregated withdrawal symptom score was the sum of the scores of the 7 withdrawal symptoms (irritability-frustration-anger, restlessness, difficulty concentrating, anxiety, dysphoric or depressed mood, insomnia, and increased appetite). The total scores are reported with a minimum possible score of 0 and a maximum possible score of 28.

Participants were asked if during the last 24 hours they experienced each of 7 withdrawal symptoms on a 5-grade categorical scale of 0 - 4 (where 0=not at all and 4=extremely so). The aggregated withdrawal symptom score was the sum of the scores of the 7 withdrawal symptoms (irritability-frustration-anger, restlessness, difficulty concentrating, anxiety, dysphoric or depressed mood, insomnia, and increased appetite). The total scores are reported with a minimum possible score of 0 and a maximum possible score of 28.

Participants were asked if during the last 24 hours they experienced each of 7 withdrawal symptoms on a 5-grade categorical scale of 0 - 4 (where 0=not at all and 4=extremely so). The aggregated withdrawal symptom score was the sum of the scores of the 7 withdrawal symptoms (irritability-frustration-anger, restlessness, difficulty concentrating, anxiety, dysphoric or depressed mood, insomnia, and increased appetite). The total scores are reported with a minimum possible score of 0 and a maximum possible score of 28.

Participants were asked if during the last 24 hours they experienced each of 7 withdrawal symptoms on a 5-grade categorical scale of 0 - 4 (where 0=not at all and 4=extremely so). The aggregated withdrawal symptom score was the sum of the scores of the 7 withdrawal symptoms (irritability-frustration-anger, restlessness, difficulty concentrating, anxiety, dysphoric or depressed mood, insomnia, and increased appetite). The total scores are reported with a minimum possible score of 0 and a maximum possible score of 28.

Total Daily Number of Self-Reported Spray Doses

Total Daily Number of Self-Reported Spray Doses

Total Daily Number of Self-Reported Spray Doses

Total Daily Number of Self-Reported Spray Doses

Total Daily Number of Self-Reported Spray Doses

Total Daily Number of Self-Reported Spray Doses

Total Daily Number of Self-Reported Spray Doses

Total Daily Number of Self-Reported Spray Doses

Total Daily Number of Self-Reported Spray Doses

Total Daily Number of Self-Reported Spray Doses

Total Daily Number of Self-Reported Spray Doses

Total Daily Number of Self-Reported Spray Doses

Total Daily Number of Self-Reported Spray Doses

Total Daily Number of Self-Reported Spray Doses

Total Daily Number of Self-Reported Spray Doses

Total Daily Number of Self-Reported Spray Doses

Total Daily Number of Self-Reported Spray Doses

Total Daily Number of Self-Reported Spray Doses

Total Daily Number of Self-Reported Spray Doses

Total Daily Number of Self-Reported Spray Doses

Total Daily Number of Self-Reported Spray Doses

Total Daily Number of Self-Reported Spray Doses

Total Daily Number of Self-Reported Spray Doses

Total Daily Number of Self-Reported Spray Doses

Total Daily Number of Self-Reported Spray Doses

Total Daily Number of Self-Reported Spray Doses

Maximum Total Daily Number of Self-Reported Spray Doses

Maximum Total Daily Number of Self-Reported Spray Doses

Maximum Total Daily Number of Self-Reported Spray Doses

Maximum Total Daily Number of Self-Reported Spray Doses

Maximum Total Daily Number of Self-Reported Spray Doses

Maximum Total Daily Number of Self-Reported Spray Doses

Maximum Total Daily Number of Self-Reported Spray Doses

Maximum Total Daily Number of Self-Reported Spray Doses

Maximum Total Daily Number of Self-Reported Spray Doses

Maximum Total Daily Number of Self-Reported Spray Doses

Maximum Total Daily Number of Self-Reported Spray Doses

Maximum Total Daily Number of Self-Reported Spray Doses

Maximum Total Daily Number of Self-Reported Spray Doses

Maximum Total Daily Number of Self-Reported Spray Doses

Maximum Total Daily Number of Self-Reported Spray Doses

Maximum Total Daily Number of Self-Reported Spray Doses

Maximum Total Daily Number of Self-Reported Spray Doses

Maximum Total Daily Number of Self-Reported Spray Doses

Maximum Total Daily Number of Self-Reported Spray Doses

Maximum Total Daily Number of Self-Reported Spray Doses

Maximum Total Daily Number of Self-Reported Spray Doses

Maximum Total Daily Number of Self-Reported Spray Doses

Maximum Total Daily Number of Self-Reported Spray Doses

Maximum Total Daily Number of Self-Reported Spray Doses

Maximum Total Daily Number of Self-Reported Spray Doses

Maximum Total Daily Number of Self-Reported Spray Doses

Maximum Hourly Number of Self-Reported Spray Doses

Maximum Hourly Number of Self-Reported Spray Doses

Maximum Hourly Number of Self-Reported Spray Doses

Maximum Hourly Number of Self-Reported Spray Doses

Maximum Hourly Number of Self-Reported Spray Doses

Maximum Hourly Number of Self-Reported Spray Doses

Maximum Hourly Number of Self-Reported Spray Doses

Maximum Hourly Number of Self-Reported Spray Doses

Maximum Hourly Number of Self-Reported Spray Doses

Maximum Hourly Number of Self-Reported Spray Doses

Maximum Hourly Number of Self-Reported Spray Doses

Maximum Hourly Number of Self-Reported Spray Doses

Maximum Hourly Number of Self-Reported Spray Doses

Maximum Hourly Number of Self-Reported Spray Doses

Maximum Hourly Number of Self-Reported Spray Doses

Maximum Hourly Number of Self-Reported Spray Doses

Maximum Hourly Number of Self-Reported Spray Doses

Maximum Hourly Number of Self-Reported Spray Doses

Maximum Hourly Number of Self-Reported Spray Doses

Maximum Hourly Number of Self-Reported Spray Doses

Maximum Hourly Number of Self-Reported Spray Doses

Maximum Hourly Number of Self-Reported Spray Doses

Maximum Hourly Number of Self-Reported Spray Doses

Maximum Hourly Number of Self-Reported Spray Doses

Maximum Hourly Number of Self-Reported Spray Doses

Maximum Hourly Number of Self-Reported Spray Doses

Number of Cigarettes Smoked Since Last Visit

Number of Cigarettes Smoked Since Last Visit

Number of Cigarettes Smoked Per Day

Number of Cigarettes Smoked Per Day

Number of Cigarettes Smoked Per Day

Number of Cigarettes Smoked Per Day

Number of Cigarettes Smoked Per Day

Number of Cigarettes Smoked Per Day

Number of Cigarettes Smoked Per Day

Participants were asked to rate the investigational product on a 10-point scale of 1 - 10 (where 1=very poor and 10=excellent).

Participants were asked to rate the investigational product on a 10-point scale of 1 - 10 (where 1=very poor and 10=excellent).

Participants were asked to rate the investigational product on a 10-point scale of 1 - 10 (where 1=very poor and 10=excellent).

Participants were asked to rate the product in its effectiveness for dealing with desire/urge to smoke on a 5-point scale of 1 - 5 (where 1=not all effective and 5=extremely effective).

Participants were asked to rate the product in its effectiveness for dealing with desire/urge to smoke on a 5-point scale of 1 - 5 (where 1=not all effective and 5=extremely effective).

Participants were asked to rate the product in its effectiveness for dealing with desire/urge to smoke on a 5-point scale of 1 - 5 (where 1=not all effective and 5=extremely effective).

Participants were asked to rate the speed of action of the product on a 9-point scale of 1 - 9 (where 1=extremely slow and 9=extremely fast).

Participants were asked to rate the speed of action of the product on a 9-point scale of 1 - 9 (where 1=extremely slow and 9=extremely fast).

Participants were asked to rate the speed of action of the product on a 9-point scale of 1 - 9 (where 1=extremely slow and 9=extremely fast).

Participants were asked to rate their change of opinion concerning product compared to when first used product on a 5-point scale of 1 - 5 (where 1=I like it much less now and 5=I like it much more now).

Participants were asked to rate their change of opinion concerning product compared to when first used product on a 5-point scale of 1 - 5 (where 1=I like it much less now and 5=I like it much more now).

Participants were asked to rate their change of opinion concerning product compared to when first used product on a 5-point scale of 1 - 5 (where 1=I like it much less now and 5=I like it much more now).

Participants were asked to rate the product convenience on a 5-point scale of 1 - 5 (where 1=not at all convenient and 5=extremely convenient).

Participants were asked to rate the product convenience on a 5-point scale of 1 - 5 (where 1=not at all convenient and 5=extremely convenient).

Participants were asked to rate the product convenience on a 5-point scale of 1 - 5 (where 1=not at all convenient and 5=extremely convenient).

Systolic blood pressure (mm Hg)

Systolic blood pressure (mm Hg)

Systolic blood pressure (mm Hg)

Systolic blood pressure (mm Hg)

Systolic blood pressure (mm Hg)

Systolic blood pressure (mm Hg)

Systolic blood pressure (mm Hg)

Systolic blood pressure (mm Hg)

Systolic blood pressure (mm Hg)

Change from baseline in systolic blood pressure (mm Hg)

Change from baseline in systolic blood pressure (mm Hg)

Change from baseline in systolic blood pressure (mm Hg)

Change from baseline in systolic blood pressure (mm Hg)

Change from baseline in systolic blood pressure (mm Hg)

Change from baseline in systolic blood pressure (mm Hg)

Change from baseline in systolic blood pressure (mm Hg)

Change from baseline in systolic blood pressure (mm Hg)

Change from baseline in systolic blood pressure (mm Hg)

Diastolic blood pressure (mm Hg)

Diastolic blood pressure (mm Hg)

Diastolic blood pressure (mm Hg)

Diastolic blood pressure (mm Hg)

Diastolic blood pressure (mm Hg)

Diastolic blood pressure (mm Hg)

Diastolic blood pressure (mm Hg)

Diastolic blood pressure (mm Hg)

Diastolic blood pressure (mm Hg)

Change from baseline in diastolic blood pressure (mm Hg)

Change from baseline in diastolic blood pressure (mm Hg)

Change from baseline in diastolic blood pressure (mm Hg)

Change from baseline in diastolic blood pressure (mm Hg)

Change from baseline in diastolic blood pressure (mm Hg)

Change from baseline in diastolic blood pressure (mm Hg)

Change from baseline in diastolic blood pressure (mm Hg)

Change from baseline in diastolic blood pressure (mm Hg)

Change from baseline in diastolic blood pressure (mm Hg)

Pulse (beats per minute)

Pulse (beats per minute)

Pulse (beats per minute)

Pulse (beats per minute)

Pulse (beats per minute)

Pulse (beats per minute)

Pulse (beats per minute)

Pulse (beats per minute)

Pulse (beats per minute)

Change from baseline in pulse (beats per minute)

Change from baseline in pulse (beats per minute)

Change from baseline in pulse (beats per minute)

Change from baseline in pulse (beats per minute)

Change from baseline in pulse (beats per minute)

Change from baseline in pulse (beats per minute)

Change from baseline in pulse (beats per minute)

Change from baseline in pulse (beats per minute)

Change from baseline in pulse (beats per minute)

Visual mouth inspection (VMI) performed at the site or local dental office by a licensed dentist or an examiner such as a dental hygienist with documented training in oral clinical exams. Extraoral and intraoral tissues were examined. Abnormalities were recorded; it was determined if abnormalities were new or had worsened since baseline VMI findings.

Visual mouth inspection (VMI) performed at the site or local dental office by a licensed dentist or an examiner such as a dental hygienist with documented training in oral clinical exams. Extraoral and intraoral tissues were examined. Abnormalities were recorded; it was determined if abnormalities were new or had worsened since baseline VMI findings.

Visual mouth inspection (VMI) performed at the site or local dental office by a licensed dentist or an examiner such as a dental hygienist with documented training in oral clinical exams. Extraoral and intraoral tissues were examined. Abnormalities were recorded; it was determined if abnormalities were new or had worsened since baseline VMI findings.

Visual mouth inspection (VMI) performed at the site or local dental office by a licensed dentist or an examiner such as a dental hygienist with documented training in oral clinical exams. Extraoral and intraoral tissues were examined. Abnormalities were recorded; it was determined if abnormalities were new or had worsened since baseline VMI findings.

Visual mouth inspection (VMI) performed at the site or local dental office by a licensed dentist or an examiner such as a dental hygienist with documented training in oral clinical exams. Extraoral and intraoral tissues were examined. Abnormalities were recorded; it was determined if abnormalities were new or had worsened since baseline VMI findings.

Visual mouth inspection (VMI) performed at the site or local dental office by a licensed dentist or an examiner such as a dental hygienist with documented training in oral clinical exams. Extraoral and intraoral tissues were examined. Abnormalities were recorded; it was determined if abnormalities were new or had worsened since baseline VMI findings.

Visual mouth inspection (VMI) performed at the site or local dental office by a licensed dentist or an examiner such as a dental hygienist with documented training in oral clinical exams. Extraoral and intraoral tissues were examined. Abnormalities were recorded; it was determined if abnormalities were new or had worsened since baseline VMI findings.

Visual mouth inspection (VMI) performed at the site or local dental office by a licensed dentist or an examiner such as a dental hygienist with documented training in oral clinical exams. Extraoral and intraoral tissues were examined. Abnormalities were recorded; it was determined if abnormalities were new or had worsened since baseline VMI findings.

Visual mouth inspection (VMI) performed at the site or local dental office by a licensed dentist or an examiner such as a dental hygienist with documented training in oral clinical exams. Extraoral and intraoral tissues were examined. Abnormalities were recorded; it was determined if abnormalities were new or had worsened since baseline VMI findings.

Change from baseline in body weight

Change from baseline in body weight

Change from baseline in body weight

Change from baseline in body weight

Change from baseline in body weight

Change from baseline in body weight