Biological Variability in Cartilage Specific Biomarkers in Healthy Volunteers.

Evaluation of Biological Variability in Cartilage Specific Biomarkers (Coll2-1, Coll2-1NO2, FIB3-1 and FIB 3-2) in Healthy Volunteers.

The purposes of the study are to assess intra individual biological variability of serum and urinary cartilage specific biomarkers and define the best standardized conditions for blood and urine sampling in the frame of biomarkers dosage.

To assess intra individual biological variability of serum and urinary cartilage specific biomarkers and define the best standardized conditions for blood and urine sampling in the frame of biomarkers dosage. Variation factors assessed are:

• Fasting condition
• Sampling time
• Sampling season
• Physical activity
• Duration and temperature of total blood treatment
• Type of blood collection tube.

Inclusion Criteria:

• Male or female, aged above 18 years.
• Sign an informed consent after being informed
• Able to follow the instructions of the study

Exclusion Criteria:

• Serious associated diseases:

  • Severe liver disease
  • Renal failure
  • HIV
  • hepatitis B or C

• Patient who are the subject of a judicial protection measure or under guardianship