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The purposes of the study are to assess intra individual biological variability of serum and urinary cartilage specific biomarkers and define the best standardized conditions for blood and urine sampling in the frame of biomarkers dosage.
To assess intra individual biological variability of serum and urinary cartilage specific biomarkers and define the best standardized conditions for blood and urine sampling in the frame of biomarkers dosage. Variation factors assessed are:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 15 healthy volunteers | Other: serum and urine sample |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| serum and urine sample | Other | Serum and urine samples will be collected at baseline, weeks2, 16, 52 and 68 to assess intra-individual biological variability of cartilage-specific biomarkers Coll2-1/Coll2-1NO2 / FIB3-1 and FIB3-2. |
| Measure | Description | Time Frame |
|---|---|---|
| Variation of serum and urine sample between baseline, weeks 2, 16, 52 and 68 to assess intra-individual biological variability of cartilage-specific biomarkers Coll2-1/Coll2-1NO2 / FIB3-1 and FIB3-2. | Change from baseline will be assess by biomarkers dosage using ELISA (Enzyme Linked ImmunoAssay) | Baseline and weeks 2, 16, 52 and 68 |
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Inclusion Criteria:
Exclusion Criteria:
Serious associated diseases:
Patient who are the subject of a judicial protection measure or under guardianship
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Male or female above 18 years
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| Name | Affiliation | Role |
|---|---|---|
| Bernard Jandrain, MD | Clinical Pharmacology Unit, ATC sa, Belgium | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| ATC SA, Unité de pharmacologie clinique, CHU Sart Tilman | Liège | Liege | 4000 | Belgium |
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Serum and urine samples