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The serum concentration of cartilage oligomeric matrix protein (sCOMP) has been considered a mechano-sensitive biomarker of articular cartilage turnover, and N-propeptide of type II collagen (PIIANP) is a proposed biomarker of type II collagen synthesis. Few studies have investigated both the anabolic and turnover response of articular cartilage as a result of acute changes in body weight mass during exercise. Using a repeated measures cross-over design, fifteen healthy adults (age 18-30 years) performed three, 30-minute bouts of treadmill walking exercise under 3 loading conditions: (1) control (no alteration to body mass); (2) loaded (12% increase in body mass using a weighted vest); and (3) unloaded (12% decrease in body mass using lower body positive pressure). Venous blood was collected before, immediately after, and 15 and 30 minutes after exercise to investigate cartilage turnover (sCOMP) and anabolism (PIIANP).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | Experimental | The control condition did 30 minutes of walking exercise with their own body mass. |
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| +12% Body Mass | Experimental | The +12% body mass condition did 30 minutes of walking exercise wearing a weighted vest with +12% of their body mass applied. |
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| -12% Body Mass | Experimental | The -12% body mass condition did 30 minutes of walking exercise using a lower body positive pressure treadmill with -12% of their body mass applied. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Control Condition | Other | Control (no alteration to body mass). |
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| Measure | Description | Time Frame |
|---|---|---|
| Serum cartilage oligomeric matrix protein (sCOMP) | The systemic blood serum concentration of sCOMP was evaluated in all participants under the 3 conditions in a crossover trial. | sCOMP was measured at baseline, immediately post, and 15- and 30-minutes post exercise. |
| N-propeptide of type II collagen (PIIANP) | The systemic blood serum concentration of PIIANP was evaluated in all participants under the 3 conditions in a crossover trial. | PIIANP was measured at baseline, immediately post, and 15- and 30-minutes post exercise. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Stephen M Cornish, PhD | University of Manitoba | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Manitoba | Winnipeg | Manitoba | R3T 2N2 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37556859 | Derived | de Vasconcelos BM, Peeler JD, Scribbans T, Cornish SM. A preliminary study on the effect of loaded and unloaded exercise on N-propeptide of type II collagen and serum cartilage oligomeric matrix protein activity of articular cartilage in healthy young adults. Appl Physiol Nutr Metab. 2023 Dec 1;48(12):954-961. doi: 10.1139/apnm-2023-0124. Epub 2023 Aug 9. |
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The data will not be available to other researchers as we do not have ethical approval to do so.
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| +12% Body Mass |
| Other |
Loaded walking exercise (12% increase in body mass using a weighted vest). |
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| -12% Body Mass | Other | Unloaded walking exercise (12% decrease in body mass using lower body positive pressure). |
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