A Clinical Study of Subclinical Enthesitis and Synovitis in Patients With Vulgaris Psoriasis

A Clinical Study of Subclinical Enthesitis and Synovitis in Patients With Vulgaris Psoriasis

A clinical study of subclinical enthesitis and synovitis in patients with vulgaris psoriasis

A total of 100 patients with vulgaris psoriasis and 100 age-matched controls with other skin diseases, all without musculoskeletal diseases, will be recruited. They will undergo dermatological assessment and a blinded PDUS evaluation. Clinical assessment included demographics, severity of psoriasis, musculoskeletal clinical examination and sport activities. PDUS evaluation consisted of the detection of grey scale (GS) synovitis and synovial PD signal in joints of extremities, GS enthesopathy and entheseal PD signal in entheses of lower limbs.

Inclusion Criteria:

• age≥18years
• patients with vulgaris psoriasis(dur
• patients with other skin diseases without musculoskeletal disorders
• no joint involvement and no clinical symptoms and signs of enthesitis and synovitis

Exclusion Criteria:

• BMI≥24
• have history of gout or arthritis or peripheral neurological disease of lower extremity or trauma
• have received any systemic therapy(i.e.NSAIDs, corticosteroids, immunosuppressants, retinoids or biological agents) in 3 months
• pregnant or breast-feeding