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The purpose of this study is to determine whether Febuxostat could protect cardiovascular function of peritoneal dialysis patients by lowering serum uric acid.
Patients with more than 3-month-history of peritoneal dialysis and hyperuricemia. Use Febuxostat to control their serum uric acid for 1 year. To observe the cardiovascular events of patients, and compare and evaluate the changes of heart function, heart construction, serum cardiac markers and brain natriuretic peptide (BNP) levels before and after Febuxostat treatment.
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| Measure | Description | Time Frame |
|---|---|---|
| cardiovascular events (heart failure, myocardial infarction, unstable angina which need hospitalization，heart surgery, or death caused by cardiovascular disease.) | heart failure, myocardial infarction, unstable angina which need hospitalization，heart surgery, or death caused by cardiovascular disease. | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Serum uric acid | blood test for serum uric acid | 1st month, 2nd month, 3rd month, 6th month, 9th month, 12th month |
| cardiovascular function (Heart construction and cardiac ejection fraction determined by echocardiography; blood test: cardiac markers including troponin,myoglobin and creatinine kinase, MB isoenzyme (CK-MB), brain natriuretic peptide) |
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Inclusion Criteria:
- Peritoneal dialysis for more than 3 months with hyperuricemia.
Exclusion Criteria:
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Peritoneal dialysis patients with hyperuricemia
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| Name | Affiliation | Role |
|---|---|---|
| Ling Wang, MD, PhD | Department of Nephrology & Rheumatology, Shanghai Tenth People's Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Nephrology & Rheumatology, Shanghai Tenth People's Hospital | Shanghai | Shanghai Municipality | 200072 | China |
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| ID | Term |
|---|---|
| D033461 | Hyperuricemia |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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Heart construction and cardiac ejection fraction determined by echocardiography; blood test: cardiac markers including troponin,myoglobin and creatinine kinase, MB isoenzyme (CK-MB), brain natriuretic peptide. |
| 6 months |