To investigate the Effect of Hyperuricaemia on Chronic Renal Disease and Intervention

This study aims to explore the best effective dose and adverse reaction of febuxostat in lowering serum uric acid to low level in patients with Chronic Renal Disease at different stages. To elucidate that low levels of serum uric acid can delay the progression of renal damage. Promote the application of anti uric acid drugs in the treatment of chronic renal failure and delay the progress of CKD in patients

Inclusion Criteria:

• Non-dialysis CKD patients with serum uric acid greater than 7mg/dl.
• eGFR≥15ml/min/1.73m².
• Low salt, low protein, low purine diet.

Exclusion Criteria:

• Take drugs that raise blood uric acid at the same time.
• Patients with gout attacks.
• Patients with pregnant, lactating.
• Autosomal dominant polycystic kidney disease.
• Patients with poor general condition and multiple organ failure.