A Phase 1 Study Comparing AVP-786 With AVP-923

A Phase 1, Single-center, Randomized, Double-blind, Double-dummy, 2-way Crossover Study Comparing AVP-786 With AVP-923

To compare pharmacokinetics (PK) of AVP-786 (deuterated [d6] dextromethorphan hydrobromide [d6-DM]/quinidine sulfate [Q]) to AVP-923 (dextromethorphan hydrobromide [DM]/Q) at steady state.

Inclusion Criteria:

• Healthy adult males or females
• 18 - 60 years of age
• BMI 18 - 32 kg/m2

Exclusion Criteria:

• History or presence of significant disease
• History of substance abuse and/or alcohol abuse with the past 2 years
• Use of tobacco-containing or nicotine-containing products within 6 months
• Use of any prescription or the over-the-counter medications within 14 days