Pharmacokinetics (PK) and Tolerability of AVP-786 in Healthy Volunteers

A Phase 1, Single-center, Randomized, Double-blind, Study to Assess the Pharmacokinetics, Safety and Tolerability of Single and Multiple Doses of AVP-786 (Deuterated Dextromethorphan) in Healthy Volunteers

To assess the single- and multiple-dose pharmacokinetic (PK), safety and tolerability of AVP-786 in healthy volunteers.

Inclusion Criteria:

• Healthy adult males
• 18 - 45 years of age
• BMI 18 - 30 kg/m2

Exclusion Criteria:

• History or presence of significant disease
• History of substance and/or alcohol abuse within the past 3 years
• Use of tobacco-containing or nicotine-contining products within 6 months
• Use of any prescription of over-the-counter (OTC) medication within 14 days