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| Name | Class |
|---|---|
| Danish Heart Foundation | OTHER |
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This randomized trial has been designed to study if it is possible to enhance work capacity during submaximal efforts in heart failure patients supported with continuous-flow left ventricular assist devices (CF-LVAD).
The hypothesis is that exercise tolerability during low to moderate workloads in CF-LVAD patients can be increased when pump speed is increased soon after the onset of exercise.
To test the hypothesis described above the investigators will study submaximal exercise tests below anaerobic threshold in patients supported with CF-LVADs.Each patient will perform two tests- one with baseline CF-LVAD pump speed and the other with incrementally increased pump speed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CF-LVAD patients. | Experimental | Patients are compared with themselves during submaximal exercise testing with baseline pump speed vs. submaximal exercise testing with increased pump speed. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CF-LVAD pump speed baseline. | Other | Submaximal exercise test with baseline pump speed. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Exercise time | Exercise will be performed on a upright ergometer bike with simultaneously breath-by-breath gaz analysis. | Exercise time will be estimated only on the day of the study. No follow-up. |
| Measure | Description | Time Frame |
|---|---|---|
| Perceived exertion | Rate of exertion will be estimated using the Borg Scale. | Perceived exertion will be estimated during exercise on the ergometer bike on the day of the study. |
| Measure | Description | Time Frame |
|---|---|---|
| Heart rate | Heart rate is measured by ECG monitoring. | Heart rate will be measures during exercise. |
| Anaerobic threshold | Anaerobic threshold is defined as respiratory exchange rate (RER) >1. |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Finn Gustafsson, MD | Rigshospitalet, Denmark | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital of Copenhagen; Rigshospitalet. | Copenhagen Oe | 2100 | Denmark |
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| ID | Term |
|---|---|
| D006333 | Heart Failure |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| CF-LVAD pump speed increased. | Other | Submaximal exercise test with increased pump speed (+800RPM). |
|
| Anaerobic threshold is measured during exercise on the study day. |