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The purpose of the study is to examine the relationship between working capacity (peak oxygen consumption) and pump speed of continuous flow left ventricular assist devices (CF-LVADs)in heart failure patients. The hypothesis is that it is possible to increase peak oxygen consumption by incrementally increasing CF-LVAD pumpspeed during exercise.
The study population will consist of severe heart failure patients with CF-LVADs treated at The Heart Centre of Copenhagen University Hospital Rigshospitalet.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CF-LVAD pumpspeed. | Experimental | Optimal pumpspeed setting of CF-LVAD during exercise on ergometric bicycle. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Incremental pump speed of CF-LVAD. | Device | Peak oxygen consumption with fixed versus incremental pump speed. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Peak oxygen consumption. | ml oxygen/minute/kg | Day 1 |
| Measure | Description | Time Frame |
|---|---|---|
| Working capacity. | Watt | Day 1 |
| Measure | Description | Time Frame |
|---|---|---|
| Exercise time (minutes), anerobic threshold. | Day 1 |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Cardiology, Copenhagen University Hospital, Rigshospitalet. | Copenhagen | 2100 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24464845 | Derived | Jung MH, Hansen PB, Sander K, Olsen PS, Rossing K, Boesgaard S, Russell SD, Gustafsson F. Effect of increasing pump speed during exercise on peak oxygen uptake in heart failure patients supported with a continuous-flow left ventricular assist device. A double-blind randomized study. Eur J Heart Fail. 2014 Apr;16(4):403-8. doi: 10.1002/ejhf.52. |
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| ID | Term |
|---|---|
| D006333 | Heart Failure |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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