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| Name | Class |
|---|---|
| University of Iowa | OTHER |
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The primary objective of this study is to evaluate the effects of the experimental treatment (cognitive training) further outlined in this protocol on the cognitive abilities (e.g., processing speed, attention, working memory, and executive function), brain functionality, functional status and quality of life of individuals with age-related cognitive decline as compared to a computer-based active control.
The normal aging has a devastating effect on our cognitive ability to learn and remember, on the speed with which the investigators process information, and on our ability to reason. By 2050, nearly 14 million individuals in the US will be living with Alzheimer's disease (AD), up from 5 million in 2013. AD is the most common cause of dementia, resulting in the loss of cognitive functions such as memory, reasoning, language, and cognitive, social, physical, and emotional control, to the extent that losses interfere with activities of daily living and necessitate continuous monitoring and care. Many studies now show that the processing machinery of the brain is plastic and remodeled throughout life by learning and experience, enabling the strengthening of cognitive skills or abilities. Research has shown that brief, daily computerized cognitive training that is sufficiently challenging, goal-directed and adaptive enables intact brain structures to restore balance in attention and compensate for disruptions in cognitive functioning. The study aims to understand how our computer program can affect cognition and attention in those with aging brain.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Computerized Plasticity-based Software | Experimental | Computerized Plasticity-based software training requiring a total maximum of 50 treatment sessions, 4-5 times weekly, 40 minutes each session. |
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| Commercially available video game | Active Comparator | Commercially available video game training. Treatment is software based, will occur up to 50 times throughout study duration, 4-5 times per week, 40 minutes each session.. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Computerized Plasticity-based Software | Behavioral | Participants will be asked to use their assigned training program for forty minutes per session, up to five sessions per week, over 10 weeks (50 total sessions). |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in performance on global cognitive composite score | Change in performance on global cognitive composite score based on the average of all normalized assessment measures. | Baseline and at the completion of 10 weeks of training |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in brain function | Change in resting state functional connectivity will be measured by resting State T2*weighted EPI-BOLD, a 10-minute task-free BOLD contrast sequence consisting of 300 volumes (TR=2000 ms/TE=30ms) at 3.4mm3 in-plane resolution and 3mm slice thickness. Participants will be instructed to keep their eyes open and maintain attention on a central gray fixation cross on a black screen. |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in Life Satisfaction | Change in life satisfaction will be measured using the age-adjusted score on General Life Satisfaction Survey from NIH Tool Box. | Baseline and at the completion of 10 weeks of training |
| Changes in Perceived Stress |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Hyunkyu Lee, Ph.D. | Posit Science | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Iowa | Iowa City | Iowa | 52242 | United States |
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| Commercially available Video Game | Behavioral | Participants will be asked to use their assigned video games for forty minutes per session, up to five sessions per week, over 10 weeks (50 total sessions). |
|
| Baseline and at the completion of 10 weeks of training |
| Changes in brain structure | 3D T1-Weighted multi-echo MPRAGE. Morphometric analyses will be based on this MRI sequence (not accelerated because the reliability of acceleration for multi-site studies has not yet been established). We will achieve spatial resolution of 1 x 1 x 1 mm voxels. | Baseline and at the completion of 10 weeks of training |
| Changes in task-related brain activation | Change in functional connectivity and brain activation will be measured while performing Flanker Task. | Baseline and at the completion of 10 weeks of training |
| Changes in performance on memory composite score | Change in performance on memory will be measured using the composite score created by averaging the z-scores of Visual Short Term Memory, Spatial Working Memory and N-Back tasks. | Baseline and at the completion of 10 weeks of training |
| Changes in performance on executive function composite score | Change in performance on executive function will be measured using the composite score created by averaging the z-scores for the Flanker, Stroop and Trail Making tasks. | Baseline and at the completion of 10 weeks of training |
| Changes in performance on processing speed composite score | Change in performance on processing speed will be measured using the composite score created by averaging the z-scores of Pattern Comparison, Letter Comparison, and Digit Symbol Coding tasks. | Baseline and at the completion of 10 weeks of training |
Change in stress will be measured using the age-adjusted score on Perceived Stress Survey from NIH Tool Box.
| Baseline and at the completion of 10 weeks of training |
| Changes in Self-Efficacy | Change in self-efficacy will be measured using the age-adjusted score on Self-Efficacy Survey from NIH Tool Box. | Baseline and at the completion of 10 weeks of training |
| Changes in Olfaction | Changes in olfaction will be measured using the age-adjusted score on Odor Identification Test from NIH Tool Box. | Baseline and at the completion of 10 weeks of training |
| Changes in Standing Balance | Changes in standing balance will be measured using age-adjusted score on Standing Balance Test from NIH Tool Box. | Baseline and at the completion of 10 weeks of training |
| Change in Physical Activity | Change in total score based on weekly self-report dairy about physical activity over a 10 week period. | Over 10 weeks |
| Change in Diet | Change in total score based on weekly self-report dairy about diet over a 10 week period. | Over 10 weeks |
| Change in Social Activity | Change in total score based on weekly self-report dairy about social activity over a 10 week period. | Over 10 weeks |
| Change in Functional Abilities | Change in total score based on weekly self-report dairy about functional abilities over a 10 week period | Over 10 weeks |