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Surgical stress creates a state of insulin resistance which has been related to increased postoperative complications. Fasting before surgery induces a catabolic state that contributes to the development of insulin resistance. The aim of this study is to evaluate the effect of preoperative oral carbohydrates on postoperative insulin resistance in patients undergoing OPCAB (off-pump coronary artery bypass surgery). Sixty patients, aged 20 to 79 years, scheduled for OPCAB will be divided into carbohydrate (n=30) and control (n=30) groups. Randomly selected patients of the carbohydrate group are given 400ml of 12.8 g/100 ml carbohydrate beverage in the evening before surgery and in the morning of the operation day (3 hours before their scheduled operation). In contrast, patients in the control group consume no food or drink after midnight before their surgery. The primary endpoints are postoperative insulin resistance measured by short insulin tolerance test.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| carbohydrate group | Experimental | Randomly selected patients of the carbohydrate group are given 400ml of 12.8 g/100 ml carbohydrate beverage in the evening before their surgery and in the morning of the operation day (3 hours before their scheduled operation). |
|
| control group | No Intervention | Patients in the control group consume no food or drink after midnight before surgery. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| carbohydrate beverage | Dietary Supplement | 400ml of 12.8 g/100 ml carbohydrate beverage |
|
| Measure | Description | Time Frame |
|---|---|---|
| postoperative insulin resistance | within 1 hour after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| preoperative discomfort | the preoperative discomfort measured by VAS (Visual Analog Scale) | 24 hours |
| perioperative hemodynamic effect | perioperative hemodynamic effect measured by amount of used vasopressors and minimum mixed venous oxygen saturation |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine | Seoul | Seoul | 120-752 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28437263 | Derived | Lee B, Soh S, Shim JK, Kim HY, Lee H, Kwak YL. Evaluation of preoperative oral carbohydrate administration on insulin resistance in off-pump coronary artery bypass patients: A randomised trial. Eur J Anaesthesiol. 2017 Nov;34(11):740-747. doi: 10.1097/EJA.0000000000000637. |
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| 24 hours |
| postoperative complications | infection, Myocardiac infarction, Acute renal failure, re-operation, death, etc | 24 hours |