Preoperative Oral Carbohydrate Treatment Minimizes Insulin Resistance

Preoperative Oral Carbohydrate Treatment in Diabetes Patients: A Randomized, Double-blind Trial

Insulin resistance is a positive protective reaction against surgery .this resistance has some negative consequences for patient health. It is associated with infectious complications. At the same time, Postoperative insulin resistance has been shown to correlate with the length of postoperative stay in hospital. Recently several clinical studies have shown that a carbohydrate-rich drink given 2 h before surgery diminishes postoperative insulin resistance in patient. The aim of our study is to investigate the influence on insulin resistance in patient with diabetes.

Insulin resistance is a positive protective reaction against surgery . As a response to surgery, activation of neuroendocrine and inflammation systems occurs as a protective reaction. However, this resistance has some negative consequences for patient health. It is associated with infectious complications. At the same time, Postoperative insulin resistance has been shown to correlate with the length of postoperative stay in hospital. Recently several clinical studies have shown that a carbohydrate-rich drink given 2 h before surgery diminishes postoperative insulin resistance in patient. The aim of our study is to investigate the influence on insulin resistance in patient with diabetes.

Inclusion Criteria:

• patients underwent elective open colorectal resection for colorectal carcinoma and electric orthopedic surgery

Exclusion Criteria:

• Weight loss greater than 10 per cent during the previous 6 months
• Renal insufficiency (creatinine, > 3 mg/dl; hemodialysis)
• Hepatic insufficiency (Child-Pugh class, ≥ B)
• Gastro-oesophageal reflux disease
• Gastrointestinal obstruction or conditions (including pharmacological treatment) known to affect gastric emptying rate