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NAION produces an ischemic insult in the optic nerve head presumably due to the hypoperfusion of the short ciliary arteries that supply it.
Intravenous injection of glucocorticoid have proven to be effective in treatment of Nonarteritic Anterior Ischemic Optic Neuropathy,but have some side effects. the investigators believe that offering them Retrobulbar Triamcinolone Acetonide Injection that might halt the progression of the visual acuity and visual field loss if our hypothesis is correct, would greatly improve their chances of avoiding blindness.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Triamcinolone Acetonide | Active Comparator | 40mg/1ml |
|
| placebo | Placebo Comparator | 1ml |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Triamcinolone Acetonide | Drug |
| ||
| placebo |
| Measure | Description | Time Frame |
|---|---|---|
| Changes of Best corrected visual acuity(BCVA) | baseline and 1month, 3month |
| Measure | Description | Time Frame |
|---|---|---|
| Changes of Visual Field | baseline and 1month, 3month |
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Inclusion Criteria:
Sudden mono ocular vision loss associated with optic disc edema and positive Marcus Gunn (<30 days)
Exclusion Criteria:
Any eye disease except NAION(Nonarteritic Anterior Ischemic Optic Neuropathy) Neurologic defect Abnormal ESR, CRP, any history of retina or vitreal surgery Severe corneal opacity which makes retina examination impossible
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| DONGYAN PAN, Dr | Contact | 86-21-31161995 | campus@126.com |
| Name | Affiliation | Role |
|---|---|---|
| shihong zhao | department of ophthalmology | Study Director |
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| ID | Term |
|---|---|
| D018917 | Optic Neuropathy, Ischemic |
| ID | Term |
|---|---|
| D009901 | Optic Nerve Diseases |
| D003389 | Cranial Nerve Diseases |
| D009422 | Nervous System Diseases |
| D005128 | Eye Diseases |
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| ID | Term |
|---|---|
| D014222 | Triamcinolone Acetonide |
| ID | Term |
|---|---|
| D014221 | Triamcinolone |
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 |
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|
| D014652 |
| Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D013259 | Steroids, Fluorinated |