In this study，the investigators want to determine the corelation between circulating nuclearsome and the development of SIRS occured after congenital cardiac surgery, including the serverity of organ damage and inflamation.

Blood was collected from study participants at 6 time points; 1) post-anesthesia induction, 2) post-op hour 0, 3) post-op hour 4, 4) post-op hour 24, 5) post-op hour 48, and 6) post-op hour 72. At each of the 6 time points blood was analyzed for levels of the following:histone,blood routine test , c-reaction protein, procalcitonin, N-terminal pro-brain natriuretic,the hepatorenal function，cardiac function and pulmonary function

Inclusion Criteria:

• children with congenial heart disease

Exclusion Criteria:

• Less than 2.5kg
• Prematurity less than 37 weeks estimated gestational age
• Renal failure as described by the pediatric RIFLE criteria

1-36 months 2.5-15 kilogram accepted congential cardiac surgery