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The autonomic nervous system state (ANSS) and the autonomic nervous system state index (ANSSi) - two indices derived from the pulse photo-plethysmography analysis - have been recently advocated as a measure of sympathetic activity in the anesthetized patients, but their validity has not been yet demonstrated. We will conduct a study aiming to assess if ANSS and ANSSi reflect autonomic nervous system modulation on cardiovascular system in healthy humans under general anaesthesia.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| autonomic nervous system analysis | Procedure | electrocardiographic and pulse-photoplethysmographic waves of patients under general anesthesia for laparoscopic cholecystectomy will be recorded on a laptop pc for offline analysis of autonomic nervous system modulation a three main time point: 1) at baseline, before general anesthesia induction, 2) five min after tracheal tube placement, 3) five min after pneumoperitoneum insufflation. |
| Measure | Description | Time Frame |
|---|---|---|
| autonomic nervous system activity during laparoscopic cholecystectomy (measured by pulse-photoplethysmography and heart rate variability analysis) | assessment of autonomic nervous system activity measured by pulse-photoplethysmography and heart rate variability analysis | 120 min |
| Measure | Description | Time Frame |
|---|---|---|
| agreement of photoplethysmography and heart rate variability | assessment of agreement between pulse-photoplethysmography and heart rate variability as a measure of autonomic nervous system activity | 120 min |
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Inclusion Criteria:
Exclusion Criteria:
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adults scheduled for elective laparoscopic cholecystectomy under general anaesthesia
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Luigi Sacco Hospital | Milan | 20157 | Italy |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22369767 | Background | Hamunen K, Kontinen V, Hakala E, Talke P, Paloheimo M, Kalso E. Effect of pain on autonomic nervous system indices derived from photoplethysmography in healthy volunteers. Br J Anaesth. 2012 May;108(5):838-44. doi: 10.1093/bja/aes001. Epub 2012 Feb 26. | |
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