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Due to reorganization.
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Specific Aim 1: To determine if one of three burn dressings provides a less painful healing experience for partial thickness hand.
Specific Aim 2: To evaluate if one of three dressings provides greater functionality during and after healing of partial thickness hand burns.
Specific Aim 3: To determine if one of three burn dressings promotes aesthetically superior healing results for partial thickness hand burns.
Various products are on the market and available for use on partial thickness burns to the hand/s. Our current institutional standard of care is to use Xeroform Gauze (Coviden, Mansfield, MA) and Bacitracin Ointment (Fougera, Melville, NY) to promote a moist antibacterial healing environment with the ability to monitor the healing progress daily. However, silver (AG) based dressings that employ nanocrystalline technology with hydrofiber (Aquacel AG burn; ConvaTec, Princeton, NJ) or soft silicone foam (Mepilex AG ; Molnlycke Health Care, Dunstable, United Kingdom) have been well accepted as alternative dressing solutions. These dressings have longer interval times between changes, leading to a reported increase in patient comfort, diminished skin shearing/stripping, and rapid re-epithelialization.
Given the anatomic intricacies, partial thickness burns to the hand present a challenge in dressing selection. Recently, ConvaTec unveiled the Aquacel AG Burn Glove for use on partial thickness hand burns. In line with this idea, our institution has now begun to fashion a novel burn glove out of Mepilex Transfer AG with good success. To date there are no known studies that compare Xeroform/Bacitracin, Aquacel AG burn glove or Mepilex Transfer AG dressing. The goal of this study is to compare these three burn dressings used to treat partial-thickness hand burns and their impact on pain, function, and aesthetic outcomes. We will also explore psychosocial issues related to hand burn dressing changes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Aquacel® Ag Burn Glove | Experimental | Application of Aquacel® Ag Burn Glove burn dressing |
|
| Mepilex® Transfer Ag | Active Comparator | Application of Mepilex® Transfer Ag burn dressing |
|
| Xeroform®/Bacitracin® | Active Comparator | Application of Xeroform® burn dressing and Bacitracin® topical antibiotic |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Aquacel® Ag Burn Glove | Other | burn dressing |
|
|
| Measure | Description | Time Frame |
|---|---|---|
| pain | pain as measured by the Patient and Provider Scar Assessment Scale | baseline to 6 months post-burn injury |
| Measure | Description | Time Frame |
|---|---|---|
| pain | pain as measured by the Michigan Hand Outcomes Questionnaire (MHQ) | baseline to 6 months post-burn injury |
| pain | pain as measured by the Disabilities of the Arm, Shoulder and Hand Scale, Quick (QuickDASH) |
| Measure | Description | Time Frame |
|---|---|---|
| quality of life | quality of life measured by the psychosocial scales: Burn Specific Health Scale (BSHS) | baseline to 6 months post-burn injury |
| resilience | resilience measured by the Connor-Davidson Resilience Scale (CD-RISC) |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Nada N Berry, MD | Southern Illinois University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Southern Illinois University School of Medicine | Springfield | Illinois | 62794-9640 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 18843629 | Background | Wasiak J, Cleland H, Campbell F. Dressings for superficial and partial thickness burns. Cochrane Database Syst Rev. 2008 Oct 8;(4):CD002106. doi: 10.1002/14651858.CD002106.pub3. | |
| 1633673 | Background | Robson MC, Smith DJ Jr, VanderZee AJ, Roberts L. Making the burned hand functional. Clin Plast Surg. 1992 Jul;19(3):663-71. |
| Label | URL |
|---|---|
| Institute for Plastic Surgery, Office for Clinical Research | View source |
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| ID | Term |
|---|---|
| D002056 | Burns |
| D002921 | Cicatrix |
| ID | Term |
|---|---|
| D014947 | Wounds and Injuries |
| D005355 | Fibrosis |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D000900 | Anti-Bacterial Agents |
| D001414 | Bacitracin |
| C004554 | 2,4,6-tribromophenol |
| ID | Term |
|---|---|
| D000890 | Anti-Infective Agents |
| D045506 | Therapeutic Uses |
| D020228 | Pharmacologic Actions |
| D020164 | Chemical Actions and Uses |
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| Mepilex® Transfer Ag | Other | burn dressing |
|
|
| antibiotic | Drug | antibiotic burn dressing |
|
|
| baseline to 6 months post-burn injury |
| functionality | functionality as measured by the Michigan Hand Outcomes Questionnaire (MHQ) | baseline to 6 months post-burn injury |
| functionality | functionality as measured by the Disabilities of the Arm, Shoulder and Hand Scale, Quick (QuickDASH) | baseline to 6 months post-burn injury |
| aesthetic appearance | scar formation and aesthetic appearance measured using the Vancouver Scar Scale | baseline to 6 months post-burn injury |
| aesthetic appearance | scar formation and aesthetic appearance measured using the the Patient and Provider Scar Assessment Scale | baseline to 6 months post-burn injury |
| baseline to 6 months post-burn injury |
| 18952379 | Background | Kamolz LP, Kitzinger HB, Karle B, Frey M. The treatment of hand burns. Burns. 2009 May;35(3):327-37. doi: 10.1016/j.burns.2008.08.004. Epub 2008 Oct 25. |
| 19686881 | Background | Walburn J, Vedhara K, Hankins M, Rixon L, Weinman J. Psychological stress and wound healing in humans: a systematic review and meta-analysis. J Psychosom Res. 2009 Sep;67(3):253-71. doi: 10.1016/j.jpsychores.2009.04.002. Epub 2009 Jul 2. |
| 17137719 | Background | Atiyeh BS, Costagliola M, Hayek SN, Dibo SA. Effect of silver on burn wound infection control and healing: review of the literature. Burns. 2007 Mar;33(2):139-48. doi: 10.1016/j.burns.2006.06.010. Epub 2006 Nov 29. |
| 8726163 | Background | Hollinger MA. Toxicological aspects of topical silver pharmaceuticals. Crit Rev Toxicol. 1996 May;26(3):255-60. doi: 10.3109/10408449609012524. |
| 15091147 | Background | Bowler PG, Jones SA, Walker M, Parsons D. Microbicidal properties of a silver-containing hydrofiber dressing against a variety of burn wound pathogens. J Burn Care Rehabil. 2004 Mar-Apr;25(2):192-6. doi: 10.1097/01.bcr.0000112331.72232.1b. |
| D010456 |
| Peptides, Cyclic |
| D047028 | Macrocyclic Compounds |
| D011083 | Polycyclic Compounds |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |