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| ID | Type | Description | Link |
|---|---|---|---|
| 2013-A01107-38 | Other Identifier | ANSM |
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Endothelial dysfunction of conduit arteries plays an important role in the development of cardiovascular complications associated with type 2 diabetes. In order to propose targeted therapeutic approaches, this study aim to determine the mechanisms involved in endothelial dysfunction of conduit arteries in these patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patient comparative approach | Experimental | Assessing the availability of biological markers (NO, EETs, ET-1 and ROS) during endothelial stimulation using blood samples. |
|
| Control subjects comparative approach | Experimental | Assessing the availability of biological markers (NO, EETs, ET-1 and ROS) during endothelial stimulation using blood samples. |
|
| Healthy volunteers metabolic approach | Experimental | Assessing the availability of biological markers (NO, EETs, ET-1 and ROS) during endothelial stimulation using blood samples during hyperglycemia or hyperinsulinemia. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood samples | Biological | Blood samples will be performed at baseline and during endothelial stimulation by hand skin heating to quantify metabolites of NO, EETs, ET-1 and ROS |
| Measure | Description | Time Frame |
|---|---|---|
| Change from Baseline in EET concentration during endothelial stimulation | 30 min from the beginning of hand skin heating |
| Measure | Description | Time Frame |
|---|---|---|
| Change from Baseline in NO concentration during endothelial stimulation | 30 min from the beginning of hand skin heating | |
| Change from Baseline in ET-1 concentration during endothelial stimulation | 30 min from the beginning of hand skin heating |
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Inclusion Criteria:
- Type 2 diabetic patients or control subjects or healthy volunteers
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Robinson JOANNIDES, MD | University Hospital, Rouen | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Rouen University Hospital | Rouen | 76031 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30885203 | Derived | Duflot T, Moreau-Grange L, Roche C, Iacob M, Wils J, Remy-Jouet I, Cailleux AF, Leuillier M, Renet S, Li D, Morisseau C, Lamoureux F, Richard V, Prevost G, Joannides R, Bellien J. Altered bioavailability of epoxyeicosatrienoic acids is associated with conduit artery endothelial dysfunction in type 2 diabetic patients. Cardiovasc Diabetol. 2019 Mar 18;18(1):35. doi: 10.1186/s12933-019-0843-z. |
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| ID | Term |
|---|---|
| D003924 | Diabetes Mellitus, Type 2 |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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| Change from Baseline in ROS concentration during endothelial stimulation | 30 min from the beginning of hand skin heating |
| D004700 | Endocrine System Diseases |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |