Mechanisms of Endothelial Dysfunction in Type 2 Diabetes

Determination of the Mechanisms Involved in Conduit Artery Endothelial Dysfunction in Type 2 Diabetes

Endothelial dysfunction of conduit arteries plays an important role in the development of cardiovascular complications associated with type 2 diabetes. In order to propose targeted therapeutic approaches, this study aim to determine the mechanisms involved in endothelial dysfunction of conduit arteries in these patients.

Inclusion Criteria:

- Type 2 diabetic patients or control subjects or healthy volunteers

Exclusion Criteria:

• Macroangiopathy
• Insulin treatment
• Chronic kidney disease (eGFR<60 ml/min/m²)
• Hyperlipidemia (total cholesterol>2.5 g/l)
• Smoking habit > 5 cigarettes/day
• Pregnancy