Exercise Training and Endothelial Function in Type 1 Diabetes

Impact of Exercise Training on Endothelial Function in Adults With Type 1 Diabetes

Endothelial dysfunction and vasoreactivity disorders are early subclinical complications of type 1 diabetes (T1D). In a preventive setting, in T1D patients still free of complications, the research of non-pharmacological interventions to improve endothelial function appears fundamental.

In this randomized controlled trial, the effects of exercise training on endothelial function will be evaluated in T1D adults. Secondary objectives are to evaluate the exercise training effects on the micro and macrovascular function and exercise-induced tissue vasoreactivity and their possible neurometabolic consequences.

An improvement in vascular function, particularly endothelium-dependent, as well as in neurometabolic profile, through this non-pharmacological strategy is expected

Inclusion Criteria:

• Covered by social security
• With a T1Diabete, diagnosed for at least 1 year, and free from macrovascular and microvascular diabetic complications.

Exclusion Criteria:

• type 1 diabetes diagnoses for less than 1 year
• MODY diabetes, mitochondrial diabetes or type 2 diabetes
• presence of macrovascular and/or microvascular diabetic complications (retinopathy, nephropathy, neuropathy ,…)
• Obesity (Body Mass Index > 30 kg/m²
• Smokers
• Hypertension
• Disabling painful discomfort for trunk, upper or lower limb movements
• Active chronic disease or in remission (excluding type 1 diabetes)
• Head trauma in the past