A Clinical Trial on the Effects of Home-based Five Plus Exercise Training

A Randomized Clinical Trial on the Effects of Home-based Five Plus Exercise Training

The aim of the study is to evaluate whether walking capacity in patients with intermittent claudication is improved more by home-based 5+ exercise training than by current recommendations of daily walking. The study will elucidate if such a potential effect is dependent on changes in mitochondrial respiratory capacity, blood flow or both.

Inclusion Criteria:

• Diagnosed with intermittent claudication secondary to vascular insufficiency
• An ankle-brachial index between 0.4 and 0.9.

Exclusion Criteria:

• Diagnosed with critical limb ischemia
• Ankle-brachial index (ABI) > 0.90 or < 0.4
• Limited exercise tolerance
• Warfarin or heparin usage
• Underwent a vascular intervention in the last 6 months
• Active cancer, renal- or liver disease