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The aim of the study is to evaluate whether walking capacity in patients with intermittent claudication is improved more by home-based 5+ exercise training than by current recommendations of daily walking. The study will elucidate if such a potential effect is dependent on changes in mitochondrial respiratory capacity, blood flow or both.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Usual care | No Intervention | ||
| Five Plus | Active Comparator | Exercise training |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Five plus exercise training | Other | calf raise exercise |
|
| Measure | Description | Time Frame |
|---|---|---|
| absolute walking distance (meters) as measured by 6 minute walking test | treadmill 3.2 km/hour and inclination increase every 2 minute combined with 6 minute walking test | 8 weeks |
| mitochondrial function measured by respirometry | Oxygen consumption (pmol O2 per second per mg of wet weight tissue) measured by respirometry | 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Arterial bloodflow measured by plethysmography | measured by plethysmography | 8 weeks |
| Quality of life assessed by SF 36 and CLAU-S questionnaires | assessed by SF 36 and CLAU-S questionnaires |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Øivind Rognmo, phd | Norwegian University of Science and Technology | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department for circulation and medical imaging, NTNU | Trondheim | Postboks 8905 | 7491 | Norway |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28285932 | Result | Van Schaardenburgh M, Wohlwend M, Rognmo O, Mattsson E. Calf raise exercise increases walking performance in patients with intermittent claudication. J Vasc Surg. 2017 May;65(5):1473-1482. doi: 10.1016/j.jvs.2016.12.106. Epub 2017 Mar 9. | |
| 28592294 | Result | van Schaardenburgh M, Wohlwend M, Rognmo O, Mattsson EJR. Exercise in claudicants increase or decrease walking ability and the response relates to mitochondrial function. J Transl Med. 2017 Jun 7;15(1):130. doi: 10.1186/s12967-017-1232-6. |
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| ID | Term |
|---|---|
| D007383 | Intermittent Claudication |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D058729 | Peripheral Arterial Disease |
| D016491 | Peripheral Vascular Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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| 8 weeks |
| Peak oxygen uptake measured by cardio-pulmonal exercise testing | measured by cardio-pulmonal exercise testing | 8 weeks |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001519 | Behavior |