The Initial Effect of Training on Mitochondrial Function in Patients With Intermittent Claudication

The Initial Effect of Training on Mitochondrial Function in Patients With Intermittent Claudication

The hypothesis of this study is that one bout of leg exercise gives acute qualitative changes in mitochondrial function in claudication. Final purpose is to determine the optimal exercise frequency in treatment of claudication.

Inclusion Criteria:

• A history of any type of uni- or bilateral exertion leg pain.
• A maximal claudication distance that is less than 300 meter
• Diagnosed with intermittent claudication secondary to vascular insufficiency
• An ankle-brachial index between 0.4 and 0.9.
• Lives in Trondheim

Exclusion Criteria:

• Diagnosed with critical limb ischemia
• ankle-brachial index > 0.90 or < 0.4
• Limited exercise tolerance
• Warfarin or heparin usage
• Diabetes mellitus
• Underwent a vascular intervention in the last 3 months
• Active cancer, renal- or liver disease.