The purpose of this study is to determine whether uFSH is effective and safe in the treatment of male patients with severe oligospermia or azoospermia.

Inclusion Criteria:

• Male subjects aged 20~35.
• They accorded with diagnostic criteria of severe oligospermia or azoospermia.
• They had'nt been treated with drug which could improve sperm count and quality one month before observation，otherwise,they should have a elution for 1 month before the study.

Exclusion Criteria:

• Gram-positive bacteria ,Chlamydia trachomatis,Ureaplasmaurealyticum,or mycoplasma hominis were detected in their semen.
• Subjects addicted to drug，tobacco，or alcohol.
• Subjects had heat,chemicals,radioactive material,or toxic contact history within a year.
• Subjects were under treatment of gonadotropin,anabolic steroid,chemotherapeutic drugs,or nonsteroidal anti-inflammatory drugs .
• Subjects combined with cardiovascular, liver, kidney ,or hematopoietic system severe primary disease,or mental disease.
• Subjects were allergic or on uFSH allergy,or under the treatment of other drugs for infertility .
• Subjects did not meet the inclusion criteria, did not according to the prescribed medication, were unable to judge the efficacy ,had incomplete information, or affected the efficacy or safety judgment.
• Subjects were IHH patients