GnRHa Combined With hCG and hMG for Treatment of Patients With Non-obstructive Azoospermia

GnRHa Combined With hCG and hMG for Treatment of Patients With Non-obstructive Azoospermia: A Single-center Prospective Study in China

Preliminary reports showed that hormonal treatment may improve the chance of retrieving viable testicular sperm from men with NOA. It was generally believed that gonadotrophin treatment would be ineffective in the presence of high plasma levels of endogenous gonadotrophin.The purpose of this study is to determine whether GnRHa(gonadotropin-releasing hormone agonist) combined with hCG(human chorionic gonadotropin) and hMG(human menopausal gonadotropin) are effective in the treatment of non-obstructive azoospermia.

Inclusion Criteria:

• Male subjects aged 18-45 with clinical diagnosis of non-obstructive azoospermia.
• At least testicular volume more than 8.0ml on one side .
• FSH more than 5.5 IU/L.

Exclusion Criteria:

• Subjects with anatomical abnormalities of the genital tract.
• allergy to the drugs used for treatment.
• Y chromosome deletions or abnormal karyotypes.
• Subjects combined with cardiovascular, liver, kidney ,or hematopoietic system severe primary disease,or mental disease