Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
This study will evaluate whether whole-body vibration applied over a 12-week period is effective in treating motor symptoms of Parkinson's disease.
Parkinson's disease (PD) is a progressive neurodegenerative disease resulting in the loss of dopaminergic neurons projecting from the substantia nigra pars compacta to the striatum.
Whole-body vibration (WBV) is potentially beneficial in treating Parkinson's disease because it has been shown to elicit effects specific to both the brain and muscular system. Animal models of PD indicate that whole-body vibration can increase striatal dopamine levels, as well as the number of dopaminergic neurons in the substantia nigra. These findings were correlated with increased levels of brain-derived neurotrophic factor.
In addition to the potentially neuroplastic effects, >20 Hz WBV has been shown to improve muscular performance. Improved muscular performance is believed to be attributed to WBV induced neuromuscular effects rather than muscle hypertrophy, with the specific mechanism defined as the tonic vibration reflex.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| whole-body vibration | Experimental | 40 Hz Whole-body vibration applied via physioaccoustic method for 12 weeks, 3 times a week |
|
| sham treatment | Sham Comparator | simulated whole-body vibration applied 3 times a week for 12 weeks |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| vibrating chair | Device | vibration provided via physioacoustic method |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Unified Parkinson's Disease Rating Scale (UPDRS) section III | clinician monitored motor evaluation | change from baseline, 12 weeks, and 2 week washout |
| Measure | Description | Time Frame |
|---|---|---|
| Gait Assessment | pressure sensitive carpet (GAITRite) measuring gait parameters (step length, step velocity, stride-to-stride variability, etc) | change from baseline, 12 weeks, and 2 week washout |
| Timed Up & Go (TUG) Test |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Adam K Koebel, BSc | Contact | 519-884-0710 | 3924 | koeb2420@mylaurier.ca |
| Patricia Freeman | Contact | 519-884-0710 | 2877 | pafreeman@wlu.ca |
| Name | Affiliation | Role |
|---|---|---|
| Adam K Koebel, BSc | Wilfrid Laurier University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sun Life Financial Movement Disorders Research & Rehabilitation Centre | Recruiting | Waterloo | Ontario | N2L 3J5 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 16720935 | Background | Haas CT, Turbanski S, Kessler K, Schmidtbleicher D. The effects of random whole-body-vibration on motor symptoms in Parkinson's disease. NeuroRehabilitation. 2006;21(1):29-36. | |
| 18295614 | Background | Ebersbach G, Edler D, Kaufhold O, Wissel J. Whole body vibration versus conventional physiotherapy to improve balance and gait in Parkinson's disease. Arch Phys Med Rehabil. 2008 Mar;89(3):399-403. doi: 10.1016/j.apmr.2007.09.031. |
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| sham treatment |
| Device |
simulated whole-body vibration |
|
|
measuring time participants take to stand up from chair, walk towards an obstacle, turn around, walk back to chair, and sit back down again
| change from baseline, 12 weeks, and 2 week washout |
| Timed Grooved Pegboard Task | 25 pegs with a key along one side must be rotated to properly be inserted into slot on board (measuring time-in and time-out) | change from baseline, 12 weeks, and 2 week washout |
| 20037223 | Background | King LK, Almeida QJ, Ahonen H. Short-term effects of vibration therapy on motor impairments in Parkinson's disease. NeuroRehabilitation. 2009;25(4):297-306. doi: 10.3233/NRE-2009-0528. |
| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |