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This prospective study with sibling oocytes will evaluate the efficiency of two commercial single-step media, namely Sage 1-step and Continuous Single Culture Medium (CSCM), in terms of embryo utilization rates, blastocyst formation rates, embryo quality and pregnancy rates. Embryos will be cultured continuously for up to 6 days under identical conditions.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sage 1-step | Active Comparator | Embryo culture in different single-step media: Half of each patient's oocytes will be randomly allocated to be cultured in Sage 1-step medium for up to six days following oocyte retrieval. |
|
| CSCM | Active Comparator | Embryo culture in different single-step media: Half of each patient's oocytes will be randomly allocated to be cultured in CSC medium for up to six days following oocyte retrieval. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| embryo culture in different single-step media | Other | Half of each patient's oocytes will be randomly allocated to be cultured either in Sage 1-step medium (Origio) or in CSC medium (Irvine Scientific) for up to six days following oocyte retrieval. |
| Measure | Description | Time Frame |
|---|---|---|
| Utilization rates | Utilization = embryos selected for transfer and cryopreservation | 6 days post oocyte retrieval |
| Blastocyst formation | Number of blastocysts on day 5 post oocyte retrieval per fertilized oocytes | 5 days post oocyte retrieval |
| Measure | Description | Time Frame |
|---|---|---|
| Embryo quality on day 3 | 3 days post oocyte retrieval | |
| blastocyst quality on day 5 | 5 days post oocyte retrieval | |
| positive pregnancy test |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Ioannis A Sfontouris, PhD | Eugonia | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Eugonia Assisted Reproduction Unit | Athens | Attica | 11528 | Greece |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28718081 | Derived | Sfontouris IA, Kolibianakis EM, Lainas GT, Venetis CA, Petsas GK, Tarlatzis BC, Lainas TG. Blastocyst utilization rates after continuous culture in two commercial single-step media: a prospective randomized study with sibling oocytes. J Assist Reprod Genet. 2017 Oct;34(10):1377-1383. doi: 10.1007/s10815-017-0997-0. Epub 2017 Jul 17. |
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| ID | Term |
|---|---|
| D007246 | Infertility |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
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| 15 days post oocyte retrieval |
| clinical pregnancy | presence of gestational sac with positive fetal heartbeat | 7 weeks of gestation |