Serum Neuroglobin and HIF-1α in Acute Ischemic Stroke

Changes of Serum Neuroglobin and HIF-1α Concentrations in Early-phase of Acute Ischemic Stroke

Neuroglobin has shown rich neuroprotective effects against cerebral ischemia and hypoxia, and therefore has the potential to impact outcomes after acute ischemic stroke. Hypoxia inducible factor (HIF)-1α is neuroprotective in several models of experimental brain injury and is increased in brain after acute cerebral infarction in humans and experimental animals.The investigators sought to examine the changes in serum neuroglobin and HIF-1α concentrations in patients with acute ischemic stroke during the initial 96-h period after stroke and assessed the relation between them and the relation of them to prognosis of such patients with acute ischemic stroke.

Inclusion Criteria:

• Clinical diagnosis of acute ischemic stroke
• Admission within 12 hours

Exclusion Criteria:

• Lacunar infarction
• Cerebral hemorrhagic infarction
• Epilepsy or epileptic persons
• History of neurological diseases, myocardial infarction, renal and hepatic abnormalities and metabolic diseases
• Contraindications to antiplatelet treatments
• Serial blood samples could not be obtained