Serum Neuroglobin and Nogo-A Concentrations in Acute Traumatic Brain Injury

Neuroglobin and Nogo-A as Biomarkers for the Prognosis of Closed Traumatic Brain Injury

Neuroglobin has been described as a marker of traumatic brain injury. Nogo-A plays an important role in mediating neuroanatomical plasticity and functional recovery following traumatic brain injury. The investigators sought to examine the changes in serum neuroglobin and Nogo-A concentrations in patients with traumatic brain injury during the initial 96-h posttraumatic period and assessed the relation of neuroglobin and Nogo-A to Glasgow Coma Score and prognosis of such patients with traumatic brain injury.

Inclusion Criteria:

• Patients who suffered head trauma and whose highest abbreviated injury score (AIS) was 3 or less (other than head injury)
• Patients who delivered to hospital within 4 h

Exclusion Criteria:

• Patients who suffered open injuries
• Patients who had existing prior neurological disease
• Patients whose serial serum samples could not be obtained
• Patients less than 18 years of age
• Patients who suffered severe life-threatening injury to organs other than the brain