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The prevalence of Chagas' disease continues high even in the developed countries. Chagasic Cardiomyopathy with preserved ventricular function is an understudied form of Chagas disease. Since a majority of patients with these changes progress to dilated form with ventricular dysfunction with all its serious consequences, it is interesting to better understand the pathophysiology of the disease at the stage where there electrocardiographic changes and preserved ventricular function. And besides, search strategies to slow the progress, or even prevent the chronic phase of the disease. For this reason the investigators will evaluate the effects of exercise training in patients with Chagas cardiomyopathy without ventricular dysfunction.
Chagasic Cardiomyopathy with preserved ventricular function is an understudied form of Chagas disease. Since a majority of patients with these changes progress to dilated form with ventricular dysfunction with all its serious consequences, it is interesting to better understand the pathophysiology of the disease at the stage where there electrocardiographic changes and preserved ventricular function. And besides, search strategies to slow the progress, or even prevent the chronic phase of the disease. For this reason the investigators will evaluate the effects of exercise training in patients with Chagas cardiomyopathy without ventricular dysfunction.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sedentary Group | No Intervention | The patients will not do exercise training | |
| Trained Group | Experimental | The patients will do exercise training for sixteen weeks. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exercise | Other | Exercise Training for 4 months |
|
| Measure | Description | Time Frame |
|---|---|---|
| Sympathetic nerve activityAutonomic control | Exercise training will improve baroreflex sensitivity and reduce sympathetic nerve activity. | 4 months |
| Measure | Description | Time Frame |
|---|---|---|
| Peak oxygen consumption | Exercise training will improve peak oxygen consumption | 4 months |
| Skeletal muscle strength | Exercise training will increase skeletal muscle strength |
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Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Carlos E Negrão | Contact | 5511 26615699 | cndnegrao@incor.usp.br | |
| Adriana S Oliveira | Contact | 5511 26615057 | adriana.sarmento@usp.br |
| Name | Affiliation | Role |
|---|---|---|
| Adriana O Sarmento | University of Sao Paulo General Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Heart Institute - HC-FMUSP | Recruiting | São Paulo | São Paulo | 05403-900 | Brazil |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32875456 | Derived | Sarmento AO, Antunes-Correa LM, Alves MJNN, Bacurau AVN, Fonseca KCB, Pessoa FG, Lobo DML, Moreira LDP, Trombetta IC, Rondon MUPB, Rondon E, Vieira MLC, Ramires FJA, do Brasileiro-Santos MS, Brum PC, Mady C, Negrao CE, Thomas S, Ianni BM. Effect of exercise training on cardiovascular autonomic and muscular function in subclinical Chagas cardiomyopathy: a randomized controlled trial. Clin Auton Res. 2021 Apr;31(2):239-251. doi: 10.1007/s10286-020-00721-1. Epub 2020 Sep 1. |
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| ID | Term |
|---|---|
| D014355 | Chagas Disease |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D014352 | Trypanosomiasis |
| D056986 | Euglenozoa Infections |
| D011528 | Protozoan Infections |
| D010272 | Parasitic Diseases |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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| 4 months |
| D007239 |
| Infections |
| D000079426 | Vector Borne Diseases |
| D001519 | Behavior |