Effects of NAVA and PSV to AECOPD Patients' Air Distribution and Dead Space

Effects of NAVA and PSV to AECOPD Patients' Air Distribution and Dead Space

Chronic obstructive pulmonary disease(COPD) is a common disease among people. Acute exacerbation of chronic obstructive pulmonary disease(AECOPD) is the acute and aggravating phase of COPD which may lead to respiratory failure. Mechanical ventilation is a very important therapy for those patients,but traditional ventilation modes have some defects, so investigators need to find new modes to solve these problems. In this study, the investigators compare neurally adjusted ventilatory assist (NAVA) and PSV to observe the effects on AECOPD patients' air distribution and dead space to determine if NAVA is a more appropriate ventilation mode for AECOPD patients.

Inclusion Criteria:

• AECOPD patients who need invasive mechanical ventilation
• Patients who can tolerate assist mechanical ventilation
• Patients who have signed ICF

Exclusion Criteria:

• Patients who are younger than 18 years old or older than 75 years old
• Patients whose respiratory center is severely inhibited
• Patients who can not stand NAVA gastric tube
• Patients who have coagulation disorders
• Patients whose vital signs are unstable
• Patients who are in other clinical trails