Olanzapine Versus Lithium in the Treatment of Acute Depression in Patients With Bipolar II or Bipolar Not Otherwise Specified(OL Study)

A Randomized, Open Label Trial of Olanzapine Versus Lithium in the Treatment of Acute Depression in Patients With Bipolar II or Bipolar Not Otherwise Specified.

Determine the efficacy and tolerability of olanzapine for treatment of acute depression in patients with bipolar II or bipolar disorder NOS compared with lithium.

Inclusion Criteria:

• major depressive episode in type2 bipolar disorder or bipolar disorder NOS.(MADRS more than 20 point)
• 18years to 65years
• subjects who sign the informed consent document

Exclusion Criteria:

• don't have Diabetes and abnormal metabolism of sugar
• not noticed as bipolar disorder
• have an organic brain disease
• pregnant or breastfeeding women
• don't have heart disease
• have actively suicidal thought(Suicidal ideation score of MADRS is 6)
• who are judged by the investigator to should be excluded from the study