This is a research study comparing the safety and efficacy of two active study medications for the treatment of bipolar I disorder.

Inclusion Criteria:

• Male or female subject, 18-70 years of age
• Female subjects of childbearing potential must be using a medically accepted means of contraception
• Each subject must have a level of understanding sufficient to perform all tests and examinations required by the protocol
• Subjects must be considered reliable

Exclusion:

• Female subjects who are either pregnant or nursing
• Uncorrected hypothyroidism or hyperthyroidism
• Narrow-angle glaucoma
• Subjects who present a serious and immediate risk of endangering him or herself