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Gelatin tannate possesses astringent, antibacterial, and anti-inflammatory properties. It is increasingly being marketed as an antidiarrheal drug. A randomized, double blind, placebo-control trial was performed to assess the effectiveness of GT in management of children with acute gastroenteritis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Gelatin Tannate | Active Comparator | Gelatin Tannate: 4 times 250 mg/daily for 5 days for children under 3. years old or 4 times 500mg/daily for 5 days for children older then 3. years and under 5 years. |
|
| Placebo | Placebo Comparator | Placebo consists of an identical formulation, except active substance. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Gelatin Tannate | Drug |
| ||
| Placebo |
| Measure | Description | Time Frame |
|---|---|---|
| Duration of diarrhea | time till the first normal stool from the onset of diarrhea or normalization number of stools and last those for 48hours | 7 days |
| Measure | Description | Time Frame |
|---|---|---|
| Need of intravenous rehydration due to diarrhea | 7 days | |
| Need of hospitalization in outpatients | 7 days | |
| Vomiting |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Hanna Szajewska, Profesor | Medical University of Warsaw | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Paediatrics, The Medical University of Warsaw, Poland | Warsaw | 01-183 | Poland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29794092 | Derived | Kolodziej M, Bebenek D, Konarska Z, Szajewska H. Gelatine tannate in the management of acute gastroenteritis in children: a randomised controlled trial. BMJ Open. 2018 May 24;8(5):e020205. doi: 10.1136/bmjopen-2017-020205. | |
| 26895988 | Derived | Michalek D, Kolodziej M, Konarska Z, Szajewska H. Efficacy and safety of gelatine tannate for the treatment of acute gastroenteritis in children: protocol of a randomised controlled trial. BMJ Open. 2016 Feb 19;6(2):e010530. doi: 10.1136/bmjopen-2015-010530. |
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| ID | Term |
|---|---|
| D003967 | Diarrhea |
| ID | Term |
|---|---|
| D012817 | Signs and Symptoms, Digestive |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| C586501 | tannate gelatin |
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Placebo consists of an identical formulation, except active substance |
|
| How many times for 7days |
| Weight gain | 7 days |
| Diarrhea recurrence | 7 days |
| Frequency of watery stools | 7 days |
| Adverse effects | 7 days |
| Severity of diarrhea due to modified Vesikari score | 7 days |