Efficacy of Lactobacillus GG With Diosmectite in Treatment Children With Acute Gastroenteritis

Efficacy of Lactobacillus GG With Diosmectite in Treatment Children With Acute Gastroenteritis: A Double Blind Randomized, Placebo- Controlled Trial

Treatment diarrhea with Lactobacillus GG or smectite has proven efficacy. A randomized, double blind, placebo-control trial was performed to assess the effectiveness of both LGG and smectite in management of children with acute gastroenteritis (AGE).

ESPGHAN agreed to use probiotics, with proven efficacy, and smectite in treatment of AGE as an adjunct to standard rehydration therapy. Among probiotics Lactobacillus GG were found to be beneficial in meta-analyses. Treatment with LGG was associated with a significant reduction in diarrhea duration.

A recent review systematically evaluated the efficacy of smectite in treating acute infections diarrhea in infants and children.

Inclusion Criteria:

• children < 5 years old
• diarrhea (defined as the passage of 3 or more loose or watery stools per day) for > 1 day but < 5 days
• inform consent sing

Exclusion Criteria:

• diarrhea < 1 or > 5 days,
• a recent history of diarrhea indicated either by parents/guardian or hospital case notes,
• underlying chronic gastrointestinal disease,
• undernutrition (weight/height ratio below the 5th percentile),
• systematic infection,
• immune defects or immunosuppressive treatment