One-visit Multi-site Intradermal Rabies Vaccination - Dose Finding

One-visit Multi-site Pre-exposure Intradermal Rabies Vaccination: Dose Finding in Healthy Adults.

To determine optimum dose level for a single visit multidose intradermal injection of rabies vaccine with the aim to induce immunological memory in all subjects.

Inclusion Criteria:

• Age ≥ 18 years
• Good health according to the investigator
• Willingness and ability to adhere to the study regimen
• Able to give informed consent

Exclusion Criteria:

• Known or suspected previous vaccination against rabies
• Known or suspected allergy against any of the vaccine components
• History of unusual or severe reactions to any previous vaccination
• Immunocompromized state due to illness or medication
• Administration of plasma or blood products three months prior to inclusion in the study
• (hydroxy)chloroquine or mefloquine use
• History of any neurological disorder including epilepsy or febrile seizures
• Pregnancy or breastfeeding
• Any current infectious disease other than seasonal cold
• Bleeding disorders or use of anticoagulants