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To assess the effects on outcome of levosimendan with respect to timing of its administration on the postoperative course of high-risk cardiac surgery patients in a retrospective observational study.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Early | Levosimendan administration within first hour of post-operative ICU admission |
| |
| Late | Levosimendan administration within 24 hours of post-operative ICU admission but after first hour |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Levosimendan | Drug |
|
| Measure | Description | Time Frame |
|---|---|---|
| In-hospital mortality | until discharge, an average of 3 weeks length of stay | |
| 1 year follow-up mortality | 1 year after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Duration of mechanical ventilation | until discharge, an average of 3 weeks length of stay | |
| Incidence of renal dysfunction | until discharge, an average of 3 weeks length of stay | |
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Inclusion Criteria:
Exclusion Criteria:
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Cardiac surgery patients
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Charité University Medicine | Berlin | State of Berlin | 10117 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25837801 | Derived | Treskatsch S, Balzer F, Geyer T, Spies CD, Kastrup M, Grubitzsch H, Wernecke KD, Erb JM, Braun JP, Sander M. Early levosimendan administration is associated with decreased mortality after cardiac surgery. J Crit Care. 2015 Aug;30(4):859.e1-6. doi: 10.1016/j.jcrc.2015.03.008. Epub 2015 Mar 13. |
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| ID | Term |
|---|---|
| D000077464 | Simendan |
| ID | Term |
|---|---|
| D006835 | Hydrazones |
| D006834 | Hydrazines |
| D009930 | Organic Chemicals |
| D011724 | Pyridazines |
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| Incidence of renal replacement therapy |
| until discharge, an average of 3 weeks length of stay |
| D006573 |
| Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |