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Recent experimental and clinical data suggest a benefit of levosimendan on the kidney function. Therefore, this retrospective, single center, matched-pairs analysis aimed to investigate whether administration of levosimendan was associated with improved renal function in cardiac surgery patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Levosimendan | study group | ||
| No Levosimendan | Control group |
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| Measure | Description | Time Frame |
|---|---|---|
| Change of plasma creatinine (Difference in renal function) | Only in patients not requiring renal replacement therapy | last available value pre-op (baseline), first available value on post-op day 1, 2, 3 and 4 |
| Change of urine output after surgery (difference in renal function) | Only in patients not requiring renal replacement therapy | post-op day 1, 2, 3, 4 |
| Cumulative incidence and duration of hemodialysis (Difference in renal function) | last day of hospital stay |
| Measure | Description | Time Frame |
|---|---|---|
| Cumulative Length of stay (hospital and ICU) | last day of hospital stay | |
| In-hospital mortality | last day of hospital stay |
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Inclusion Criteria:
Exclusion Criteria:
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Patients undergoing cardiac surgery between 2007 and 2011 followed by postoperative observation on an ICU of the anaesthesiology department of the Charité hospital
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Charité - University Medicine Berlin | Berlin | State of Berlin | 10117 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 17331245 | Background | Mehta RL, Kellum JA, Shah SV, Molitoris BA, Ronco C, Warnock DG, Levin A; Acute Kidney Injury Network. Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit Care. 2007;11(2):R31. doi: 10.1186/cc5713. | |
| 18056154 | Background | Yakut N, Yasa H, Bahriye Lafci B, Ortac R, Tulukoglu E, Aksun M, Ozbek C, Gurbuz A. The influence of levosimendan and iloprost on renal ischemia-reperfusion: an experimental study. Interact Cardiovasc Thorac Surg. 2008 Apr;7(2):235-9. doi: 10.1510/icvts.2007.161356. Epub 2007 Dec 3. |
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| 25399779 | Derived | Balzer F, Treskatsch S, Spies C, Sander M, Kastrup M, Grubitzsch H, Wernecke KD, Braun JP. Early administration of levosimendan is associated with improved kidney function after cardiac surgery - a retrospective analysis. J Cardiothorac Surg. 2014 Nov 18;9:167. doi: 10.1186/s13019-014-0167-8. |