Morbidity in Patients With Hypertension and Obstructive Sleep Apnea

Morbidity in Patients With Hypertension and Obstructive Sleep Apnea

MORPHEOS is a multicenter, randomized, unblinded study, for patients diagnosed with uncontrolled hypertension and at least one antihypertensive medication. Those patients with significant sleep apnea wil be randomized to CPAP or nasal strips for 6 months.

Inclusion Criteria:

• Systolic blood pressure ≥140 mm Hg or diastolic blood pressure ≥ 90 mm Hg
• Current treatment with at least 1 antihypertensive drug

Exclusion Criteria:

• Age <18 and >65 years
• BMI ≥ 40 kg/m2
• Heart failure, EF < 45%, acute myocardial infarction, stroke, significant valvular dysfunction
• Chronic renal failure (serum creatinine > 2 mg/dL)
• Use of cocaine, amphetamines, alcohol, illicit drugs
• Use of sympathomimetics (decongestants, appetite suppressants)
• Use of oral contraceptives and chronic use of NSAIDs
• Pregnancy
• Secondary causes of hypertension (other than sleep apnea)